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Gene

F7

coagulation factor VII

Summary

Cytogenetic location
13q34
Coordinates
Chromosome 13: 113,105,791–113,120,685 (GRCh38)
Exons
8 exons across 14.9 kb
Protein
444 amino acids
MANE Select transcript
ENST00000346342.8NM_019616.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Rare Inherited Coagulation Factor Deficiencies

    • Factor VII DeficiencyAutosomal recessive

      A deficiency of clotting factor VII, mainly caused by changes in F7; bleeding severity varies widely and does not always match factor levels.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      Actionability

      Results help plan treatment, such as recombinant factor VIIa, for surgery and childbirth.

    • Congenital Vitamin K-Dependent Coagulation Factor DeficienciesAutosomal recessive

      Inherited deficiencies of prothrombin (factor II), factor VII or factor X, or of all vitamin K-dependent factors together (caused by changes in GGCX or VKORC1), which can cause nosebleeds, easy bruising and bleeding after injury, surgery or childbirth.

      • 4 GenCC submitters rate it definitive or strong
      Actionability

      Knowing in advance allows factor replacement to be planned around surgery and childbirth; the combined form often responds to vitamin K.

How F7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 13, with a bracket where F7 sits. F7 and 12 genes near it on chromosome 13, from 112,613,238 to 113,613,237.Chromosome 1313q34p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34112.8 Mb113 Mb113.2 Mb113.4 Mb113.6 MbATP11A: 112,689,911–112,887,177, forward strandATP11AMCF2L: 112,894,330–113,100,412, forward strandMCF2LF7: 113,105,791–113,120,685, forward strandF7F10: 113,122,771–113,149,531, forward strandF10PROZ: 113,158,388–113,173,625, forward strandPROZPCID2: 113,177,117–113,209,458, reverse strandPCID2CUL4A: 113,208,193–113,267,108, forward strandCUL4ALAMP1: 113,297,088–113,324,413, forward strandLAMP1GRTP1: 113,320,007–113,364,165, reverse strandGRTP1ADPRHL1: 113,399,611–113,453,914, reverse strandADPRHL1DCUN1D2: 113,455,289–113,490,984, reverse strandDCUN1D2SLC9D1: 113,490,719–113,554,590, forward strandSLC9D1TFDP1: 113,584,525–113,641,509, forward strandTFDP1Diagram of F7: 8 exons on the forward strand of chromosome 13Exon 1: 2 known disease-causing sitesExon 2: 9 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 5 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 8: 31 known disease-causing sitesExon 1: 113,105,791–113,105,905, 115 basesExon 2: 113,110,690–113,110,850, 161 basesExon 3: 113,113,752–113,113,776, 25 basesExon 4: 113,113,847–113,113,960, 114 basesExon 5: 113,115,660–113,115,800, 141 basesExon 6: 113,116,766–113,116,875, 110 basesExon 7: 113,117,473–113,117,596, 124 basesExon 8: 113,118,413–113,120,685, 2,273 bases124685′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.1 kb of the gene's 14.9 kb; 1,335 of those bases code for the protein.

Sequencing F7

5Low

How hard F7 is to sequence with short reads, out of 100

  • Mappability0.4%
  • Homology0%
  • Repeats18%
  • GC content18%
  • Reference coverage0%

68

positions in F7 where ClinVar classes a change as pathogenic or likely pathogenic

4 of them (5.9%) fall in regions short reads find hard.

  • Low mappability (4 sites)

A whole genome covers all 14.9 kb of F7, introns included, not only the 3.1 kb of exons.

Genes linked to the same conditions

Traits linked to F7

The Human Phenotype Ontology lists these as features of the rare conditions F7 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). F7 gene: coagulation factor VII. Retrieved 17 October 2026, from https://dantelabs.com/genes/f7

Vancouver

Dante Labs. F7 gene: coagulation factor VII [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/f7

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