Trait

Abnormally heavy bleeding during menstruation

Clinical name: Menorrhagia

Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.

HPO HP:0000132

Also called: Abnormally heavy periods, Hypermenorrhea
Body system: Abnormality of blood and blood-forming tissues Abnormality of the genitourinary system

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43 genes linked to Abnormally heavy bleeding during menstruation

Changes in these genes cause rare conditions in which Abnormally heavy bleeding during menstruation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
APOLD1apolipoprotein L domain containing 1	Always	In 1 condition
DTNBP1dystrobrevin binding protein 1	Always	In 1 condition
F7coagulation factor VII	Always	In 2 conditions
FLI1Fli-1 proto-oncogene, ETS transcription factor	Always	In 1 condition
FYB1FYN binding protein 1	Always	In 1 condition
GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Always	In 1 condition
GP1BAglycoprotein Ib platelet subunit alpha	Always	In 3 conditions
HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2	Always	In 1 condition
ITGB3integrin subunit beta 3	Always	In 3 conditions
LRP6LDL receptor related protein 6	Always	In 1 condition
PRKACGprotein kinase cAMP-activated catalytic subunit gamma	Always	In 1 condition
PTPRJprotein tyrosine phosphatase receptor type J	Always	In 1 condition
RASGRP2RAS guanyl releasing protein 2	Always	In 1 condition
TPM4tropomyosin 4	Very often (80–99%)	In 1 condition
BLOC1S3biogenesis of lysosomal organelles complex 1 subunit 3	Often (30–79%)	In 1 condition
BLOC1S5biogenesis of lysosomal organelles complex 1 subunit 5	Often (30–79%)	In 1 condition
F11coagulation factor XI	Often (30–79%)	In 1 condition
F8coagulation factor VIII	Often (30–79%)	In 2 conditions
GP1BBglycoprotein Ib platelet subunit beta	Often (30–79%)	In 2 conditions
GP9glycoprotein IX platelet	Often (30–79%)	In 2 conditions
HPS5HPS5 biogenesis of lysosomal organelles complex 2 subunit 2	Often (30–79%)	In 1 condition
MYH9myosin heavy chain 9	Often (30–79%)	In 2 conditions
PRLRprolactin receptor	Often (30–79%)	In 2 conditions
SERPINE1serpin family E member 1	Often (30–79%)	In 2 conditions
ANO6anoctamin 6	Sometimes (5–29%)	In 1 condition
DIAPH1diaphanous related formin 1	Sometimes (5–29%)	In 1 condition
F10coagulation factor X	Sometimes (5–29%)	In 2 conditions
F13A1coagulation factor XIII A chain	Sometimes (5–29%)	In 1 condition
F13Bcoagulation factor XIII B chain	Sometimes (5–29%)	In 1 condition
F2coagulation factor II, thrombin	Sometimes (5–29%)	In 2 conditions
F5coagulation factor V	Sometimes (5–29%)	In 2 conditions
GGCXgamma-glutamyl carboxylase	Sometimes (5–29%)	In 1 condition
ITGA2Bintegrin subunit alpha 2b	Sometimes (5–29%)	In 2 conditions
LMAN1lectin, mannose binding 1	Sometimes (5–29%)	In 1 condition
MCFD2multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	Sometimes (5–29%)	In 2 conditions
SLC37A4solute carrier family 37 member 4	Sometimes (5–29%)	In 1 condition
VKORC1vitamin K epoxide reductase complex subunit 1	Sometimes (5–29%)	In 1 condition
PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma	Rarely (1–4%)	In 1 condition
GP6glycoprotein VI platelet	Not recorded	In 1 condition
NBEAL2neurobeachin like 2	Not recorded	In 1 condition

Show 3 more genes

Gene	How often it is seen	Conditions
PLAUplasminogen activator, urokinase	Not recorded	In 1 condition
SLFN14schlafen family member 14	Not recorded	In 1 condition
VWFvon Willebrand factor	Not recorded	In 3 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the menstrual cycle Bleeding tendency

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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