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Gene

FGB

fibrinogen beta chain

Summary

Cytogenetic location
4q31.3
Coordinates
Chromosome 4: 154,563,011–154,572,807 (GRCh38)
Exons
8 exons across 9.8 kb
Protein
491 amino acids
MANE Select transcript
ENST00000302068.9NM_005141.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Afibrinogenemia

    • Congenital Fibrinogen Deficiency

      Congenital deficiencies of fibrinogen are coagulation disorders characterized by bleeding symptoms ranging from mild to severe resulting from reduced quantity and/or quality of circulating fibrinogen. Afibrinogenemia (complete absence of fibrinogen) and hypofibrinogenemia (reduced plasma fibrinogen concentration) correspond to quantitative anomalies of fibrinogen while dysfibrinogenemia corresponds to a functional anomaly of fibrinogen. Hypo- and dysfibrinogenemia may be frequently combined (hypodysfibrinogenemia).

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

How FGB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where FGB sits. FGB and 6 genes near it on chromosome 4, from 154,067,909 to 155,067,908.Chromosome 44q31.3p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2154.2 Mb154.4 Mb154.6 Mb154.8 Mb155 MbDCHS2: 154,231,742–154,491,804, reverse strandDCHS2PLRG1: 154,535,005–154,550,415, reverse strandPLRG1FGB: 154,563,011–154,572,807, forward strandFGBFGA: 154,581,966–154,590,751, reverse strandFGAFGG: 154,604,058–154,612,967, reverse strandFGGLRAT: 154,626,945–154,753,158, forward strandLRATRBM46: 154,781,213–154,828,813, forward strandRBM46Diagram of FGB: 8 exons on the forward strand of chromosome 4Exon 2: 3 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 8: 1 known disease-causing siteExon 1: 154,563,011–154,563,132, 122 basesExon 2: 154,565,808–154,565,999, 192 basesExon 3: 154,566,489–154,566,672, 184 basesExon 4: 154,567,593–154,567,820, 228 basesExon 5: 154,568,381–154,568,494, 114 basesExon 6: 154,569,182–154,569,307, 126 basesExon 7: 154,569,514–154,569,799, 286 basesExon 8: 154,570,419–154,572,807, 2,389 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.6 kb of the gene's 9.8 kb; 1,476 of those bases code for the protein.

How a genome test reads FGB

8

positions in FGB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.8 kb of FGB, introns included, not only the 3.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FGB gene: fibrinogen beta chain. Retrieved 17 October 2026, from https://dantelabs.com/genes/fgb

Vancouver

Dante Labs. FGB gene: fibrinogen beta chain [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fgb

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