Trait

Bleeding below the skin

Clinical name: Subcutaneous hemorrhage

This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses).

HPO HP:0001933

Also called: Subcutaneous haemorrhage
Body system: Abnormality of blood and blood-forming tissues Abnormality of the cardiovascular system Abnormality of the integument

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15 genes linked to Bleeding below the skin

Changes in these genes cause rare conditions in which Bleeding below the skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
EPHB2EPH receptor B2	Always	In 1 condition
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2	Very often (80–99%)	In 1 condition
ADAMTSL2ADAMTS like 2	Very often (80–99%)	In 1 condition
ARL6IP6ARF like GTPase 6 interacting protein 6	Very often (80–99%)	In 1 condition
CHST14carbohydrate sulfotransferase 14	Very often (80–99%)	In 1 condition
DSEdermatan sulfate epimerase	Very often (80–99%)	In 1 condition
GNA11G protein subunit alpha 11	Very often (80–99%)	In 1 condition
SLC35A1solute carrier family 35 member A1	Very often (80–99%)	In 2 conditions
F13A1coagulation factor XIII A chain	Often (30–79%)	In 1 condition
F13Bcoagulation factor XIII B chain	Often (30–79%)	In 1 condition
F8coagulation factor VIII	Often (30–79%)	In 1 condition
PROS1protein S	Often (30–79%)	In 1 condition
PTENphosphatase and tensin homolog	Often (30–79%)	In 1 condition
SERPINE1serpin family E member 1	Often (30–79%)	In 1 condition
CBScystathionine beta-synthase	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Bleeding tendency Vascular skin abnormality

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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