Gene
FYB1
FYN binding protein 1
- HGNC 4036(opens in a new tab)
- Ensembl gene ENSG00000082074(opens in a new tab)
- NCBI Gene 2533(opens in a new tab)
Summary
- Cytogenetic location
- 5p13.1
- Coordinates
- Chromosome 5: 39,105,252–39,219,563 (GRCh38)
- Exons
- 19 exons across 114.3 kb
- Protein
- 829 amino acids
- Also known as
- SLAP-130, FYB-120/130, ADAP
- Previous symbols
- FYB
- MANE Select transcript
- ENST00000512982.4NM_001465.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Inherited Thrombocytopenias
- Inherited Thrombocytopenia
A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.
- ClinGen rates the link moderate
- 2 GenCC submitters rate it definitive or strong
What knowing changes
A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.
How FYB1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.8 kb of the gene's 114.3 kb; 2,490 of those bases code for the protein.
Traits linked to FYB1
The Human Phenotype Ontology lists these as features of the rare conditions FYB1 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). FYB1 gene: FYN binding protein 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/fyb1
Dante Labs. FYB1 gene: FYN binding protein 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fyb1
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