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Gene

FERMT3

FERM domain containing kindlin 3

Summary

Cytogenetic location
11q13.1
Coordinates
Chromosome 11: 64,206,721–64,223,891 (GRCh38)
Exons
15 exons across 17.2 kb
Protein
663 amino acids
Inheritance
Autosomal recessive
Also known as
URP2, KIND3, MIG2B, MGC10966, UNC112C
MANE Select transcript
ENST00000345728.10NM_031471.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Leukocyte Adhesion Deficiency

    • Autosomal recessive

      Defective white cell adhesion caused by changes in both copies of ITGB2, SLC35C1 or FERMT3.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Severe forms are treated with stem cell transplantation; type 2 may respond to oral fucose, and antibiotic prophylaxis and dental care reduce infections.

  • Osteopetrosis

    • Osteopetrosis, also known as marble bone disease, is a descriptive term that refers to a group of rare, heritable disorders of the skeleton characterized by increased bone density on radiographs.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How FERMT3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where FERMT3 sits. FERMT3 and 31 genes near it on chromosome 11, from 63,715,306 to 64,715,305.Chromosome 1111q13.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2563.8 Mb64 Mb64.2 Mb64.4 Mb64.6 MbRTN3: 63,681,444–63,759,909, forward strandRTN3ZFTA: 63,759,892–63,769,752, reverse strandZFTASPINDOC: 63,813,405–63,827,718, forward strandSPINDOCMARK2: 63,838,852–63,911,020, forward strandMARK2RCOR2: 63,910,992–63,919,787, reverse strandRCOR2NAA40: 63,938,669–63,957,324, forward strandNAA40COX8A: 63,974,579–63,976,543, forward strandCOX8AOTUB1: 63,985,853–64,001,811, forward strandOTUB1MACROD1: 63,998,553–64,166,501, reverse strandMACROD1FLRT1: 64,035,757–64,119,403, forward strandFLRT1STIP1: 64,185,272–64,204,549, forward strandFERMT3: 64,206,721–64,223,891, forward strandFERMT3TRPT1: 64,223,799–64,226,823, reverse strandTRPT1NUDT22: 64,225,941–64,230,686, forward strandNUDT22DNAJC4: 64,230,158–64,234,286, forward strandDNAJC4VEGFB: 64,234,406–64,239,264, forward strandFKBP2: 64,241,003–64,244,583, forward strand: 64,241,095–64,244,583, forward strandPPP1R14B: 64,244,478–64,246,956, reverse strandPLCB3: 64,251,498–64,269,424, forward strandBAD: 64,269,828–64,291,946, reverse strandBADGPR137: 64,270,062–64,290,690, forward strandKCNK4: 64,291,302–64,300,031, forward strandKCNK4CATSPERZ: 64,300,338–64,304,770, forward strandCATSPERZESRRA: 64,305,080–64,317,859, forward strandTRMT112: 64,316,460–64,318,086, reverse strandPRDX5: 64,317,977–64,321,827, forward strandCCDC88B: 64,340,197–64,357,534, forward strandRPS6KA4: 64,359,134–64,372,215, forward strandRPS6KA4SLC22A11: 64,555,632–64,572,875, forward strandSLC22A11SLC22A12: 64,590,641–64,602,353, forward strandSLC22A12NRXN2: 64,606,174–64,723,202, reverse strandNRXN2Diagram of FERMT3: 15 exons on the forward strand of chromosome 11Exon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 1: 64,206,721–64,206,814, 94 basesExon 2: 64,207,351–64,207,524, 174 basesExon 3: 64,210,611–64,210,844, 234 basesExon 4: 64,211,052–64,211,171, 120 basesExon 5: 64,211,275–64,211,443, 169 basesExon 6: 64,211,645–64,211,747, 103 basesExon 7: 64,219,251–64,219,358, 108 basesExon 8: 64,219,524–64,219,658, 135 basesExon 9: 64,219,740–64,219,789, 50 basesExon 10: 64,219,891–64,220,015, 125 basesExon 11: 64,220,220–64,220,326, 107 basesExon 12: 64,220,436–64,220,669, 234 basesExon 13: 64,221,016–64,221,140, 125 basesExon 14: 64,223,048–64,223,189, 142 basesExon 15: 64,223,313–64,223,891, 579 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 17.2 kb; 1,992 of those bases code for the protein.

How a genome test reads FERMT3

20

positions in FERMT3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 17.2 kb of FERMT3, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FERMT3 gene: FERM domain containing kindlin 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/fermt3

Vancouver

Dante Labs. FERMT3 gene: FERM domain containing kindlin 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fermt3

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