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Gene

F13A1

coagulation factor XIII A chain

Summary

Cytogenetic location
6p25.1
Coordinates
Chromosome 6: 6,144,084–6,320,662 (GRCh38)
Exons
15 exons across 176.6 kb
Protein
732 amino acids
Inheritance
Autosomal recessive
Previous symbols
F13A
MANE Select transcript
ENST00000264870.8NM_000129.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rare Inherited Coagulation Factor Deficiencies

    • Congenital Factor XIII DeficiencyAutosomal recessive

      A deficiency of the clot-stabilising factor XIII, caused by changes in F13A1 or F13B, that can cause umbilical cord bleeding in newborns, poor wound healing, miscarriage and bleeding inside the skull; routine clotting tests are normal.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Regular preventive factor XIII replacement greatly reduces the risk of serious bleeding.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How F13A1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where F13A1 sits. F13A1 and 3 genes near it on chromosome 6, from 5,732,373 to 6,732,372.Chromosome 66p25.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q275.8 Mb6 Mb6.2 Mb6.4 Mb6.6 MbFARS2: 5,261,007–5,829,192, forward strandFARS2NRN1: 5,997,999–6,008,688, reverse strandNRN1F13A1: 6,144,084–6,320,662, reverse strandF13A1LY86: 6,588,108–6,654,984, forward strandLY86Diagram of F13A1: 15 exons on the reverse strand of chromosome 6Exon 15: 2 known disease-causing sitesExon 14: 3 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 2: 1 known disease-causing siteExon 15: 6,144,084–6,145,772, 1,689 basesExon 14: 6,151,813–6,151,949, 137 basesExon 13: 6,167,458–6,167,618, 161 basesExon 12: 6,174,580–6,174,867, 288 basesExon 11: 6,181,988–6,182,141, 154 basesExon 10: 6,195,797–6,195,885, 89 basesExon 9: 6,197,223–6,197,326, 104 basesExon 8: 6,222,033–6,222,171, 139 basesExon 7: 6,224,686–6,224,860, 175 basesExon 6: 6,248,312–6,248,419, 108 basesExon 5: 6,250,811–6,250,929, 119 basesExon 4: 6,266,558–6,266,809, 252 basesExon 3: 6,305,351–6,305,539, 189 basesExon 2: 6,318,535–6,318,682, 148 basesExon 1: 6,320,587–6,320,662, 76 bases1510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 176.6 kb; 2,199 of those bases code for the protein.

How a genome test reads F13A1

24

positions in F13A1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 176.6 kb of F13A1, introns included, not only the 3.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). F13A1 gene: coagulation factor XIII A chain. Retrieved 17 October 2026, from https://dantelabs.com/genes/f13a1

Vancouver

Dante Labs. F13A1 gene: coagulation factor XIII A chain [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/f13a1

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