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Gene

SH2B3

SH2B adaptor protein 3

Summary

Cytogenetic location
12q24.12
Coordinates
Chromosome 12: 111,405,923–111,451,623 (GRCh38)
Exons
8 exons across 45.7 kb
Protein
575 amino acids
Also known as
LNK, IDDM20
MANE Select transcript
ENST00000341259.7NM_005475.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SH2B3 yet. The test sequences your whole genome, so your data includes it all the same.

How SH2B3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where SH2B3 sits. SH2B3 and 10 genes near it on chromosome 12, from 110,928,773 to 111,928,772.Chromosome 1212q24.12p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33111 Mb111.2 Mb111.4 Mb111.6 Mb111.8 MbCUX2: 111,033,723–111,350,554, forward strandCUX2PHETA1: 111,360,651–111,369,173, reverse strandPHETA1SH2B3: 111,405,923–111,451,623, forward strandSH2B3ATXN2: 111,443,485–111,599,676, reverse strandATXN2BRAP: 111,642,145–111,686,005, reverse strandBRAPACAD10: 111,686,037–111,757,145, forward strandACAD10: 111,753,890–111,791,418, forward strandALDH2: 111,766,887–111,817,532, forward strandALDH2MAPKAPK5: 111,841,998–111,902,222, forward strandMAPKAPK5: 111,842,237–111,842,368, forward strandTMEM116: 111,893,714–112,014,271, reverse strandTMEM116Diagram of SH2B3: 8 exons on the forward strand of chromosome 12Exon 2: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 1: 111,405,923–111,406,277, 355 basesExon 2: 111,418,119–111,418,877, 759 basesExon 3: 111,446,753–111,446,854, 102 basesExon 4: 111,446,942–111,447,033, 92 basesExon 5: 111,447,125–111,447,219, 95 basesExon 6: 111,447,330–111,447,544, 215 basesExon 7: 111,447,656–111,447,827, 172 basesExon 8: 111,447,983–111,451,623, 3,641 bases1585′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 45.7 kb; 1,728 of those bases code for the protein.

How a genome test reads SH2B3

2

positions in SH2B3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 45.7 kb of SH2B3, introns included, not only the 5.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SH2B3 gene: SH2B adaptor protein 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/sh2b3

Vancouver

Dante Labs. SH2B3 gene: SH2B adaptor protein 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sh2b3

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