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Gene

CLPB

ClpB family mitochondrial disaggregase

Summary

Cytogenetic location
11q13.4
Coordinates
Chromosome 11: 72,285,495–72,434,531 (GRCh38)
Exons
16 exons across 149 kb
Protein
677 amino acids
Also known as
SKD3, FLJ13152, ANKCLP
MANE Select transcript
ENST00000538039.6NM_001258392.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

How CLPB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where CLPB sits. CLPB and 21 genes near it on chromosome 11, from 71,860,013 to 72,860,012.Chromosome 1111q13.4p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2572 Mb72.2 Mb72.4 Mb72.6 Mb72.8 MbXNDC1N-ZNF705EP-ALG1L9P: 71,804,997–71,928,656, reverse strandXNDC1N-ZNF705EP-ALG1L9PXNDC1N: 71,865,504–71,928,917, reverse strandXNDC1NDEFB131B: 71,878,453–71,884,561, forward strandDEFB131BRNF121: 71,929,005–71,997,597, forward strandRNF121IL18BP: 71,998,613–72,007,315, forward strandIL18BPNUMA1: 72,002,860–72,080,693, reverse strandLRRC51: 72,080,286–72,096,895, forward strandLRTOMT: 72,080,331–72,110,782, forward strandLRTOMTLAMTOR1: 72,085,520–72,103,393, reverse strandTOMT: 72,103,506–72,111,546, forward strandTOMTANAPC15: 72,106,370–72,113,688, reverse strandANAPC15FOLR3: 72,114,869–72,141,085, forward strandFOLR3FOLR1: 72,189,529–72,199,329, forward strandFOLR1FOLR2: 72,216,601–72,221,957, forward strandFOLR2INPPL1: 72,223,524–72,239,184, forward strandINPPL1PHOX2A: 72,239,077–72,245,664, reverse strandPHOX2ACLPB: 72,285,495–72,434,531, reverse strandCLPBPDE2A: 72,576,141–72,674,591, reverse strandPDE2AARAP1: 72,682,436–72,794,047, reverse strandARAP1STARD10: 72,753,216–72,794,047, reverse strandSTARD10ATG16L2: 72,814,138–72,845,036, forward strandATG16L2FCHSD2: 72,836,042–73,142,485, reverse strandFCHSD2Diagram of CLPB: 16 exons on the reverse strand of chromosome 11Exon 14: 3 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 3 known disease-causing sitesExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 3 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 4 known disease-causing sitesExon 16: 72,285,495–72,293,615, 8,121 basesExon 15: 72,294,022–72,294,126, 105 basesExon 14: 72,294,325–72,294,444, 120 basesExon 13: 72,294,620–72,294,693, 74 basesExon 12: 72,295,492–72,295,648, 157 basesExon 11: 72,301,803–72,301,964, 162 basesExon 10: 72,302,304–72,302,348, 45 basesExon 9: 72,307,199–72,307,254, 56 basesExon 8: 72,308,527–72,308,604, 78 basesExon 7: 72,317,106–72,317,220, 115 basesExon 6: 72,329,707–72,329,804, 98 basesExon 5: 72,358,880–72,359,008, 129 basesExon 4: 72,380,281–72,380,384, 104 basesExon 3: 72,402,966–72,403,052, 87 basesExon 2: 72,430,312–72,430,363, 52 basesExon 1: 72,434,072–72,434,531, 460 bases161510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10 kb of the gene's 149 kb; 2,034 of those bases code for the protein.

How a genome test reads CLPB

37

positions in CLPB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 149 kb of CLPB, introns included, not only the 10 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CLPB gene: ClpB family mitochondrial disaggregase. Retrieved 16 October 2026, from https://dantelabs.com/genes/clpb

Vancouver

Dante Labs. CLPB gene: ClpB family mitochondrial disaggregase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/clpb

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