Skip to content
Use your HSA or FSA funds

Gene

GFI1B

growth factor independent 1B transcriptional repressor

Summary

Cytogenetic location
9q34.13
Coordinates
Chromosome 9: 132,978,694–132,991,687 (GRCh38)
Exons
7 exons across 13 kb
Protein
330 amino acids
Also known as
ZNF163B
MANE Select transcript
ENST00000372122.4NM_001377304.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Thrombocytopenias

    • Inherited Thrombocytopenia

      A group of conditions causing a lifelong low platelet count, linked to genes such as MYH9, ANKRD26, ETV6, WAS, MPL, RBM8A, GATA1 and MECOM, and inherited in dominant, recessive or X-linked patterns.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      A genetic diagnosis avoids misdiagnosis as immune thrombocytopenia, with unnecessary steroids or spleen removal, and guides monitoring for related kidney, hearing or blood problems.

How GFI1B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where GFI1B sits. GFI1B and 25 genes near it on chromosome 9, from 132,485,191 to 133,485,190.Chromosome 99q34.13p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3132.6 Mb132.8 Mb133 Mb133.2 Mb133.4 MbCFAP77: 132,410,043–132,573,319, forward strandCFAP77DDX31: 132,536,999–132,670,401, reverse strandDDX31BARHL1: 132,582,071–132,591,651, forward strandBARHL1GTF3C4: 132,670,023–132,694,953, forward strandGTF3C4AK8: 132,725,573–132,878,777, reverse strandAK8SPACA9: 132,878,027–132,890,316, forward strandSPACA9TSC1: 132,891,348–132,946,874, reverse strandTSC1GFI1B: 132,978,694–132,991,687, forward strandGFI1BGTF3C5: 133,030,675–133,058,503, forward strandGTF3C5CEL: 133,061,981–133,071,861, forward strandCELRALGDS: 133,097,657–133,149,440, reverse strandRALGDS: 133,098,121–133,163,914, reverse strandGBGT1: 133,151,020–133,164,245, reverse strandGBGT1OBP2B: 133,205,277–133,209,309, reverse strandOBP2BABO: 133,233,278–133,276,024, reverse strandABOSURF6: 133,328,684–133,336,289, reverse strandSURF6MED22: 133,338,312–133,348,140, reverse strandMED22RPL7A: 133,347,950–133,351,435, forward strandRPL7ASURF1: 133,351,069–133,356,676, reverse strandSURF1SURF2: 133,356,520–133,362,917, forward strandSURF4: 133,361,450–133,376,233, reverse strandSTKLD1: 133,376,332–133,406,096, forward strandREXO4: 133,406,026–133,418,096, reverse strandREXO4ADAMTS13: 133,414,358–133,459,402, forward strandADAMTS13CACFD1: 133,459,965–133,470,848, forward strandCACFD1SLC2A6: 133,462,053–133,479,148, reverse strandSLC2A6Diagram of GFI1B: 7 exons on the forward strand of chromosome 9Exon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 1: 132,978,694–132,978,841, 148 basesExon 2: 132,986,659–132,986,778, 120 basesExon 3: 132,987,282–132,987,419, 138 basesExon 4: 132,988,197–132,988,468, 272 basesExon 5: 132,989,061–132,989,198, 138 basesExon 6: 132,989,742–132,989,907, 166 basesExon 7: 132,990,872–132,991,687, 816 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 13 kb; 993 of those bases code for the protein.

How a genome test reads GFI1B

5

positions in GFI1B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13 kb of GFI1B, introns included, not only the 1.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GFI1B gene: growth factor independent 1B transcriptional repressor. Retrieved 17 October 2026, from https://dantelabs.com/genes/gfi1b

Vancouver

Dante Labs. GFI1B gene: growth factor independent 1B transcriptional repressor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gfi1b

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test