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Gene

F11

coagulation factor XI

Summary

Cytogenetic location
4q35.2
Coordinates
Chromosome 4: 186,266,189–186,289,681 (GRCh38)
Exons
15 exons across 23.5 kb
Protein
625 amino acids
Inheritance
X-linked recessive
Also known as
FXI
MANE Select transcript
ENST00000403665.7NM_000128.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Haemophilia

    • HemophiliaX-linked recessive

      A group of bleeding disorders caused by deficiency of coagulation factor VIII (haemophilia A) or factor IX (haemophilia B).

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Factor replacement therapy, extended half-life factor products, emicizumab (bispecific antibody), immune tolerance therapy

Inheritance

X-linked recessive
The change is on the X chromosome, so one copy affects males, who have one X, while females with one are usually carriers. A carrier mother passes it on to each child with a one-in-two chance.

How F11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where F11 sits. F11 and 9 genes near it on chromosome 4, from 185,777,935 to 186,777,934.Chromosome 44q35.2p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2185.8 Mb186 Mb186.2 Mb186.4 Mb186.6 MbSORBS2: 185,585,444–185,956,721, reverse strandSORBS2TLR3: 186,068,911–186,088,073, forward strandTLR3FAM149A: 186,104,419–186,175,437, forward strandFAM149ACYP4V2: 186,191,258–186,215,245, forward strandCYP4V2: 186,208,979–186,258,469, forward strandKLKB1: 186,225,424–186,258,476, forward strandKLKB1F11: 186,266,189–186,289,681, forward strandF11: 186,426,546–186,555,328, reverse strandMTNR1A: 186,526,792–186,555,567, reverse strandMTNR1AFAT1: 186,586,717–186,726,722, reverse strandFAT1Diagram of F11: 15 exons on the forward strand of chromosome 4Exon 2: 4 known disease-causing sitesExon 3: 18 known disease-causing sitesExon 4: 7 known disease-causing sitesExon 5: 13 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 7: 20 known disease-causing sitesExon 8: 6 known disease-causing sitesExon 9: 19 known disease-causing sitesExon 10: 11 known disease-causing sitesExon 11: 26 known disease-causing sitesExon 12: 25 known disease-causing sitesExon 13: 20 known disease-causing sitesExon 14: 5 known disease-causing sitesExon 15: 9 known disease-causing sitesExon 1: 186,266,189–186,266,295, 107 basesExon 2: 186,267,136–186,267,191, 56 basesExon 3: 186,271,609–186,271,771, 163 basesExon 4: 186,273,071–186,273,177, 107 basesExon 5: 186,274,116–186,274,275, 160 basesExon 6: 186,275,787–186,275,896, 110 basesExon 7: 186,276,231–186,276,390, 160 basesExon 8: 186,280,012–186,280,121, 110 basesExon 9: 186,280,223–186,280,385, 163 basesExon 10: 186,280,474–186,280,580, 107 basesExon 11: 186,284,092–186,284,260, 169 basesExon 12: 186,285,638–186,285,813, 176 basesExon 13: 186,286,415–186,286,510, 96 basesExon 14: 186,287,684–186,287,823, 140 basesExon 15: 186,288,453–186,289,681, 1,229 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.1 kb of the gene's 23.5 kb; 1,878 of those bases code for the protein.

How a genome test reads F11

199

positions in F11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 23.5 kb of F11, introns included, not only the 3.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). F11 gene: coagulation factor XI. Retrieved 16 October 2026, from https://dantelabs.com/genes/f11

Vancouver

Dante Labs. F11 gene: coagulation factor XI [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/f11

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