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Gene

MEN1

menin 1

Summary

Cytogenetic location
11q13.1
Coordinates
Chromosome 11: 64,803,516–64,810,551 (GRCh38)
Exons
10 exons across 7 kb
Protein
610 amino acids
Inheritance
Autosomal dominant
MANE Select transcript
ENST00000450708.7NM_001370259.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Malignant Endocrine Neoplasm

    • Multiple Endocrine NeoplasiaAutosomal dominant

      Multiple endocrine neoplasia (MEN) is a group of rare inherited cancer syndromes characterized by the development of two or more endocrine gland tumors, sometimes with tumor development in other tissues or organs.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      • On the ACMG secondary findings list

  • Thyroid Cancer

    • Parathyroid Gland Disorder

      A disease involving the parathyroid gland.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      • On the ACMG secondary findings list

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How MEN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 11, with a bracket where MEN1 sits. MEN1 and 38 genes near it on chromosome 11, from 64,307,034 to 65,307,033.Chromosome 1111q13.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2564.4 Mb64.6 Mb64.8 Mb65 Mb65.2 MbESRRA: 64,305,080–64,317,859, forward strandTRMT112: 64,316,460–64,318,086, reverse strandTRMT112PRDX5: 64,317,977–64,321,827, forward strandPRDX5CCDC88B: 64,340,197–64,357,534, forward strandCCDC88BRPS6KA4: 64,359,134–64,372,215, forward strandRPS6KA4SLC22A11: 64,555,632–64,572,875, forward strandSLC22A11SLC22A12: 64,590,641–64,602,353, forward strandSLC22A12NRXN2: 64,606,174–64,723,202, reverse strandNRXN2RASGRP2: 64,726,905–64,745,456, reverse strandRASGRP2PYGM: 64,746,389–64,759,990, reverse strandPYGMSF1: 64,764,605–64,778,802, reverse strandSF1MAP4K2: 64,784,918–64,803,245, reverse strandMAP4K2MEN1: 64,803,516–64,810,551, reverse strandMEN1CDC42BPG: 64,823,051–64,844,735, reverse strandCDC42BPGEHD1: 64,851,642–64,888,372, reverse strandEHD1ATG2A: 64,894,531–64,917,249, reverse strandATG2APPP2R5B: 64,917,553–64,934,480, forward strandPPP2R5BGPHA2: 64,934,471–64,935,894, reverse strandGPHA2MAJIN: 64,937,517–64,972,113, reverse strandMAJINBATF2: 64,987,945–64,997,018, reverse strandBATF2ARL2: 65,013,735–65,024,328, forward strandARL2ARL2-SNX15: 65,014,182–65,040,570, forward strandARL2-SNX15SNX15: 65,027,404–65,040,578, forward strandSNX15SAC3D1: 65,040,897–65,047,320, forward strandNAALADL1: 65,044,818–65,058,558, reverse strandCDCA5: 65,066,299–65,084,164, reverse strandZFPL1: 65,084,210–65,088,409, forward strandZFPL1CATSPERH: 65,084,974–65,089,375, reverse strandVPS51: 65,089,324–65,111,862, forward strandVPS51TM7SF2: 65,111,845–65,116,677, forward strandTM7SF2ZNHIT2: 65,116,403–65,117,701, reverse strandFAU: 65,120,182–65,122,221, reverse strandSYVN1: 65,121,780–65,146,912, reverse strandMRPL49: 65,122,183–65,127,371, forward strandSPDYC: 65,166,137–65,173,380, forward strandSPDYCCAPN1: 65,180,566–65,212,006, forward strandCAPN1POLA2: 65,261,835–65,305,959, forward strandPOLA2: 65,261,928–65,326,543, forward strandCDC42EP2: 65,298,955–65,322,662, forward strandCDC42EP2Diagram of MEN1: 10 exons on the reverse strand of chromosome 11Exon 10: 87 known disease-causing sitesExon 9: 53 known disease-causing sitesExon 8: 33 known disease-causing sitesExon 7: 41 known disease-causing sitesExon 6: 16 known disease-causing sitesExon 5: 10 known disease-causing sitesExon 4: 36 known disease-causing sitesExon 3: 56 known disease-causing sitesExon 2: 129 known disease-causing sitesExon 10: 64,803,516–64,804,816, 1,301 bases. 17 variants with a page in exon 10. List themExon 9: 64,805,034–64,805,198, 165 bases. 11 variants with a page in exon 9. List themExon 8: 64,805,635–64,805,770, 136 bases. 4 variants with a page in exon 8. List themExon 7: 64,806,232–64,806,368, 137 bases. 8 variants with a page in exon 7. List themExon 6: 64,807,011–64,807,098, 88 bases. 2 variants with a page in exon 6. List themExon 5: 64,807,179–64,807,219, 41 bases. 2 variants with a page in exon 5. List themExon 4: 64,807,552–64,807,680, 129 bases. 7 variants with a page in exon 4. List themExon 3: 64,807,891–64,808,099, 209 bases. 11 variants with a page in exon 3. List themExon 2: 64,809,665–64,810,132, 468 bases. 26 variants with a page in exon 2. List themExon 1: 64,810,514–64,810,551, 38 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 7 kb; 1,833 of those bases code for the protein.

How a genome test reads MEN1

504

positions in MEN1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7 kb of MEN1, introns included, not only the 2.7 kb of exons.

Variants with a page (103)

The MEN1 variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
A176Pc.526G>CExon 364,808,019Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
A242Hfs*6c.723_724delExon 464,807,610Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
A242Vc.725C>TExon 464,807,610Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
A380Sfs*29c.1136dupExon 864,805,683Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
A467Gfs*59c.1400_1413delExon 1064,804,753Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
A467Rfs*98c.1375_1391dupExon 1064,804,775Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.1A>GExon 264,810,109Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.1A>TExon 264,810,109Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.3G>AExon 264,810,107Pathogenic/likely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts
c.196_200dupExon 264,809,909Pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts

See all 103 MEN1 variants →

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MEN1 gene: menin 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/men1

Vancouver

Dante Labs. MEN1 gene: menin 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/men1

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