Trait
Hyperinsulinemia
An increased concentration of insulin in the blood.
Summary
- Also called
- Elevated insulin level
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test142 genes linked to Hyperinsulinemia
Changes in these genes cause rare conditions in which Hyperinsulinemia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| INSRinsulin receptor | Always | In 3 conditions |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Always | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Always | In 1 condition |
| PLIN1perilipin 1 | Always | In 1 condition |
| PPARGperoxisome proliferator activated receptor gamma | Always | In 1 condition |
| PTBP1polypyrimidine tract binding protein 1 | Always | In 1 condition |
| SLC25A36solute carrier family 25 member 36 | Always | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Very often (80–99%) | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Very often (80–99%) | In 2 conditions |
| DCAF17DDB1 and CUL4 associated factor 17 | Very often (80–99%) | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Very often (80–99%) | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Very often (80–99%) | In 1 condition |
| LEPleptin | Very often (80–99%) | In 1 condition |
| LEPRleptin receptor | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 4 conditions |
| MEN1menin 1 | Very often (80–99%) | In 1 condition |
| SH2B1SH2B adaptor protein 1 | Very often (80–99%) | In 1 condition |
| SIM1SIM bHLH transcription factor 1 | Very often (80–99%) | In 1 condition |
| YY1YY1 transcription factor | Very often (80–99%) | In 1 condition |
| ABCA4ATP binding cassette subfamily A member 4 | Often (30–79%) | In 1 condition |
| ADCY3adenylate cyclase 3 | Often (30–79%) | In 1 condition |
| AGBL5AGBL carboxypeptidase 5 | Often (30–79%) | In 1 condition |
| AHI1Abelson helper integration site 1 | Often (30–79%) | In 1 condition |
| AHRaryl hydrocarbon receptor | Often (30–79%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Often (30–79%) | In 2 conditions |
| ARHGEF18Rho/Rac guanine nucleotide exchange factor 18 | Often (30–79%) | In 1 condition |
| ARL2BPARF like GTPase 2 binding protein | Often (30–79%) | In 1 condition |
| ARL3ARF like GTPase 3 | Often (30–79%) | In 1 condition |
| ARL6ARF like GTPase 6 | Often (30–79%) | In 1 condition |
| BBS1Bardet-Biedl syndrome 1 | Often (30–79%) | In 1 condition |
| BBS2Bardet-Biedl syndrome 2 | Often (30–79%) | In 1 condition |
| BEST1bestrophin 1 | Often (30–79%) | In 1 condition |
| CA4carbonic anhydrase 4 | Often (30–79%) | In 1 condition |
| CAVIN1caveolae associated protein 1 | Often (30–79%) | In 1 condition |
| CC2D2Acoiled-coil and C2 domain containing 2A | Often (30–79%) | In 1 condition |
| CDHR1cadherin related family member 1 | Often (30–79%) | In 1 condition |
| CERKLCERK like autophagy regulator | Often (30–79%) | In 1 condition |
| CFAP20cilia and flagella associated protein 20 | Often (30–79%) | In 1 condition |
| CFAP418cilia and flagella associated protein 418 | Often (30–79%) | In 1 condition |
| CLRN1clarin 1 | Often (30–79%) | In 1 condition |
Show 102 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CNGA1cyclic nucleotide gated channel subunit alpha 1 | Often (30–79%) | In 1 condition |
| CNGB1cyclic nucleotide gated channel subunit beta 1 | Often (30–79%) | In 1 condition |
| COQ8Bcoenzyme Q8B | Often (30–79%) | In 1 condition |
| CPEcarboxypeptidase E | Often (30–79%) | In 1 condition |
| CRB1crumbs cell polarity complex component 1 | Often (30–79%) | In 1 condition |
| CRXcone-rod homeobox | Often (30–79%) | In 1 condition |
| DHDDSdehydrodolichyl diphosphate synthase subunit | Often (30–79%) | In 1 condition |
| DHX38DEAH-box helicase 38 | Often (30–79%) | In 1 condition |
| DIS3L2DIS3 like 3'-5' exoribonuclease 2 | Often (30–79%) | In 1 condition |
| ESR1estrogen receptor 1 | Often (30–79%) | In 2 conditions |
| EYSEGF-like photoreceptor maintenance factor | Often (30–79%) | In 1 condition |
| FAM161AFAM161 centrosomal protein A | Often (30–79%) | In 1 condition |
| FSCN2fascin actin-bundling protein 2, retinal | Often (30–79%) | In 1 condition |
| FSD1Lfibronectin type III and SPRY domain containing 1 like | Often (30–79%) | In 1 condition |
| GUCA1Bguanylate cyclase activator 1B | Often (30–79%) | In 1 condition |
| HGSNATheparan-alpha-glucosaminide N-acetyltransferase | Often (30–79%) | In 1 condition |
| HKDC1hexokinase domain containing 1 | Often (30–79%) | In 1 condition |
| HNF1AHNF1 homeobox A | Often (30–79%) | In 1 condition |
| IDH3Aisocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha | Often (30–79%) | In 1 condition |
| IDH3Bisocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | Often (30–79%) | In 1 condition |
| IFT140intraflagellar transport 140 | Often (30–79%) | In 1 condition |
| IFT172intraflagellar transport 172 | Often (30–79%) | In 1 condition |
| IFT43intraflagellar transport 43 | Often (30–79%) | In 1 condition |
| IFT88intraflagellar transport 88 | Often (30–79%) | In 1 condition |
| IMPDH1inosine monophosphate dehydrogenase 1 | Often (30–79%) | In 1 condition |
| IMPG1interphotoreceptor matrix proteoglycan 1 | Often (30–79%) | In 1 condition |
| IMPG2interphotoreceptor matrix proteoglycan 2 | Often (30–79%) | In 1 condition |
| KIAA1549KIAA1549 | Often (30–79%) | In 1 condition |
| KIZkizuna centrosomal protein | Often (30–79%) | In 1 condition |
| KLHL7kelch like family member 7 | Often (30–79%) | In 1 condition |
| LRATlecithin retinol acyltransferase | Often (30–79%) | In 1 condition |
| MAKmale germ cell associated kinase | Often (30–79%) | In 1 condition |
| MERTKMER proto-oncogene, tyrosine kinase | Often (30–79%) | In 1 condition |
| NEK2NIMA related kinase 2 | Often (30–79%) | In 1 condition |
| NR2E3nuclear receptor subfamily 2 group E member 3 | Often (30–79%) | In 1 condition |
| NRLneural retina leucine zipper | Often (30–79%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Often (30–79%) | In 1 condition |
| PCAREphotoreceptor cilium actin regulator | Often (30–79%) | In 1 condition |
| PDE6Aphosphodiesterase 6A | Often (30–79%) | In 1 condition |
| PDE6Bphosphodiesterase 6B | Often (30–79%) | In 1 condition |
| PDE6Gphosphodiesterase 6G | Often (30–79%) | In 1 condition |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Often (30–79%) | In 1 condition |
| PRCDphotoreceptor disc component | Often (30–79%) | In 1 condition |
| PROM1prominin 1 | Often (30–79%) | In 1 condition |
| PRPF3pre-mRNA processing factor 3 | Often (30–79%) | In 1 condition |
| PRPF31pre-mRNA processing factor 31 | Often (30–79%) | In 1 condition |
| PRPF4pre-mRNA splicing tri-snRNP complex factor PRPF4 | Often (30–79%) | In 1 condition |
| PRPF6pre-mRNA processing factor 6 | Often (30–79%) | In 1 condition |
| PRPF8pre-mRNA processing factor 8 | Often (30–79%) | In 1 condition |
| PRPH2peripherin 2 | Often (30–79%) | In 1 condition |
| RBP3retinol binding protein 3 | Often (30–79%) | In 1 condition |
| RDH12retinol dehydrogenase 12 | Often (30–79%) | In 1 condition |
| REEP6receptor accessory protein 6 | Often (30–79%) | In 1 condition |
| RGRretinal G protein coupled receptor | Often (30–79%) | In 1 condition |
| RHOrhodopsin | Often (30–79%) | In 1 condition |
| RLBP1retinaldehyde binding protein 1 | Often (30–79%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Often (30–79%) | In 1 condition |
| RNU6-1RNA, U6 small nuclear 1 | Often (30–79%) | In 1 condition |
| RNU6-2RNA, U6 small nuclear 2 | Often (30–79%) | In 1 condition |
| RNU6-8RNA, U6 small nuclear 8 | Often (30–79%) | In 1 condition |
| RNU6-9RNA, U6 small nuclear 9 | Often (30–79%) | In 1 condition |
| ROM1retinal outer segment membrane protein 1 | Often (30–79%) | In 1 condition |
| RP1RP1 axonemal microtubule associated | Often (30–79%) | In 1 condition |
| RP1L1RP1 like 1 | Often (30–79%) | In 1 condition |
| RP2RP2 activator of ARL3 GTPase | Often (30–79%) | In 1 condition |
| RP9RP9 pre-mRNA splicing factor | Often (30–79%) | In 1 condition |
| RPE65retinoid isomerohydrolase RPE65 | Often (30–79%) | In 1 condition |
| RPGRretinitis pigmentosa GTPase regulator | Often (30–79%) | In 1 condition |
| SAGS-antigen visual arrestin | Often (30–79%) | In 1 condition |
| SAXO6stabilizer of axonemal microtubules 6 | Often (30–79%) | In 1 condition |
| SCAPERS-phase cyclin A associated protein in the ER | Often (30–79%) | In 1 condition |
| SEMA4Asemaphorin 4A | Often (30–79%) | In 1 condition |
| SLC7A14solute carrier family 7 member 14 | Often (30–79%) | In 1 condition |
| SNRNP200small nuclear ribonucleoprotein U5 subunit 200 | Often (30–79%) | In 1 condition |
| SPATA7spermatogenesis associated 7 | Often (30–79%) | In 1 condition |
| TMEM216transmembrane protein 216 | Often (30–79%) | In 1 condition |
| TOPORSTOP1 binding arginine/serine rich protein, E3 ubiquitin ligase | Often (30–79%) | In 1 condition |
| TTC8tetratricopeptide repeat domain 8 | Often (30–79%) | In 1 condition |
| TUBTUB bipartite transcription factor | Often (30–79%) | In 1 condition |
| TULP1TUB like protein 1 | Often (30–79%) | In 1 condition |
| USH2Ausherin | Often (30–79%) | In 1 condition |
| ZNF408zinc finger protein 408 | Often (30–79%) | In 1 condition |
| ZNF513zinc finger protein 513 | Often (30–79%) | In 1 condition |
| GALK1galactokinase 1 | Sometimes (5–29%) | In 1 condition |
| INSinsulin | Sometimes (5–29%) | In 1 condition |
| MC4Rmelanocortin 4 receptor | Sometimes (5–29%) | In 2 conditions |
| PCSK1proprotein convertase subtilisin/kexin type 1 | Sometimes (5–29%) | In 1 condition |
| PMM2phosphomannomutase 2 | Sometimes (5–29%) | In 1 condition |
| POMCproopiomelanocortin | Sometimes (5–29%) | In 1 condition |
| SMC5structural maintenance of chromosomes 5 | Sometimes (5–29%) | In 1 condition |
| DBHdopamine beta-hydroxylase | Rarely (1–4%) | In 1 condition |
| AGPAT21-acylglycerol-3-phosphate O-acyltransferase 2 | Not recorded | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Not recorded | In 1 condition |
| MAGEL2MAGE family member L2 | Not recorded | In 1 condition |
| MKRN3makorin ring finger protein 3 | Not recorded | In 1 condition |
| NPAP1nuclear pore associated protein 1 | Not recorded | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Not recorded | In 1 condition |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Not recorded | In 1 condition |
| SLC16A1solute carrier family 16 member 1 | Not recorded | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Not recorded | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Not recorded | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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