Trait
High blood calcium levels
Clinical name: Hypercalcemia
The concentration of calcium in the blood circulation is above the upper limit of normal.
Summary
- Also called
- Increased calcium in blood, Elevated calcium(2+) concentration, Elevated calcium(2+) level, Elevated calcium(2+) level in blood, Hypercalcaemia, Increased calcium(2+) concentration, Increased calcium(2+) level, Increased calcium(2+) level in blood
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to High blood calcium levels, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test83 genes linked to High blood calcium levels
Changes in these genes cause rare conditions in which High blood calcium levels is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CASRcalcium sensing receptor | Always | In 2 conditions |
| CDC73cell division cycle 73 | Always | In 6 conditions |
| CYP24A1cytochrome P450 family 24 subfamily A member 1 | Always | In 1 condition |
| GCM2GCM transcription factor 2 | Always | In 2 conditions |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| KLklotho | Always | In 1 condition |
| MARK2microtubule affinity regulating kinase 2 | Always | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Always | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Always | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Very often (80–99%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Very often (80–99%) | In 1 condition |
| CDKN1Bcyclin dependent kinase inhibitor 1B | Very often (80–99%) | In 2 conditions |
| CDKN2Bcyclin dependent kinase inhibitor 2B | Very often (80–99%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Very often (80–99%) | In 1 condition |
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Very often (80–99%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Very often (80–99%) | In 1 condition |
| ELNelastin | Very often (80–99%) | In 2 conditions |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Very often (80–99%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Very often (80–99%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Very often (80–99%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Very often (80–99%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Very often (80–99%) | In 1 condition |
| MEN1menin 1 | Very often (80–99%) | In 4 conditions |
| METTL27methyltransferase like 27 | Very often (80–99%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Very often (80–99%) | In 1 condition |
| RFC2replication factor C subunit 2 | Very often (80–99%) | In 1 condition |
| STX1Asyntaxin 1A | Very often (80–99%) | In 1 condition |
| TBL2transducin beta like 2 | Very often (80–99%) | In 1 condition |
| TMEM270transmembrane protein 270 | Very often (80–99%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Very often (80–99%) | In 1 condition |
| ANKHANKH inorganic pyrophosphate transport regulator | Often (30–79%) | In 1 condition |
| DLSTdihydrolipoamide S-succinyltransferase | Often (30–79%) | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Often (30–79%) | In 1 condition |
| EPAS1endothelial PAS domain protein 1 | Often (30–79%) | In 1 condition |
| FHfumarate hydratase | Often (30–79%) | In 1 condition |
| KIF1Bkinesin family member 1B | Often (30–79%) | In 2 conditions |
| MAXMYC associated transcriptional regulator X | Often (30–79%) | In 2 conditions |
| MDH2malate dehydrogenase 2 | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Often (30–79%) | In 1 condition |
Show 43 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha | Often (30–79%) | In 2 conditions |
| PTH1Rparathyroid hormone 1 receptor | Often (30–79%) | In 2 conditions |
| RETret proto-oncogene | Often (30–79%) | In 3 conditions |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SDHAF2succinate dehydrogenase complex assembly factor 2 | Often (30–79%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Often (30–79%) | In 2 conditions |
| SDHCsuccinate dehydrogenase complex subunit C | Often (30–79%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Often (30–79%) | In 2 conditions |
| SLC25A11solute carrier family 25 member 11 | Often (30–79%) | In 1 condition |
| TMEM127transmembrane protein 127 | Often (30–79%) | In 2 conditions |
| VHLvon Hippel-Lindau tumor suppressor | Often (30–79%) | In 3 conditions |
| BCL2BCL2 apoptosis regulator | Sometimes (5–29%) | In 1 condition |
| BCL6BCL6 transcription repressor | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BTNL2butyrophilin like 2 | Sometimes (5–29%) | In 1 condition |
| CCND1cyclin D1 | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| CTR9CTR9 component of Paf1/RNA polymerase II complex | Sometimes (5–29%) | In 1 condition |
| DIS3L2DIS3 like 3'-5' exoribonuclease 2 | Sometimes (5–29%) | In 1 condition |
| GPC3glypican 3 | Sometimes (5–29%) | In 1 condition |
| H19H19 imprinted maternally expressed transcript | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 2 conditions |
| IGHimmunoglobulin heavy locus | Sometimes (5–29%) | In 1 condition |
| LDHAlactate dehydrogenase A | Sometimes (5–29%) | In 1 condition |
| MLXIPLMLX interacting protein like | Sometimes (5–29%) | In 1 condition |
| NOTCH3notch receptor 3 | Sometimes (5–29%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| POU6F2POU class 6 homeobox 2 | Sometimes (5–29%) | In 1 condition |
| RESTRE1 silencing transcription factor | Sometimes (5–29%) | In 1 condition |
| SLC5A1solute carrier family 5 member 1 | Sometimes (5–29%) | In 1 condition |
| TRIM28tripartite motif containing 28 | Sometimes (5–29%) | In 1 condition |
| TRIOtrio Rho guanine nucleotide exchange factor | Sometimes (5–29%) | In 1 condition |
| TRIP13thyroid hormone receptor interactor 13 | Sometimes (5–29%) | In 1 condition |
| WT1WT1 transcription factor | Sometimes (5–29%) | In 1 condition |
| ZFXzinc finger protein X-linked | Sometimes (5–29%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Rarely (1–4%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Rarely (1–4%) | In 1 condition |
| ALPLalkaline phosphatase, biomineralization associated | Not recorded | In 1 condition |
| AP2S1adaptor related protein complex 2 subunit sigma 1 | Not recorded | In 1 condition |
| CDKN1Ccyclin dependent kinase inhibitor 1C | Not recorded | In 1 condition |
| GNA11G protein subunit alpha 11 | Not recorded | In 1 condition |
| SLC12A1solute carrier family 12 member 1 | Not recorded | In 1 condition |
| SLC34A1solute carrier family 34 member 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks