Trait
Hyperinsulinemic hypoglycemia
An increased concentration of insulin combined with a decreased concentration of glucose in the blood.
Summary
- Also called
- Hyperinsulinaemic hypoglycaemia, Hyperinsulinemia hypoglycemia
Reference genomeGRCh38hg38
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Get my Genome Test27 genes linked to Hyperinsulinemic hypoglycemia
Changes in these genes cause rare conditions in which Hyperinsulinemic hypoglycemia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCC8ATP binding cassette subfamily C member 8 | Always | In 4 conditions |
| GCKglucokinase | Always | In 3 conditions |
| GLUD1glutamate dehydrogenase 1 | Always | In 2 conditions |
| HADHhydroxyacyl-CoA dehydrogenase | Always | In 2 conditions |
| INSRinsulin receptor | Always | In 2 conditions |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Always | In 4 conditions |
| TRMT10AtRNA methyltransferase 10A | Always | In 1 condition |
| HNF1AHNF1 homeobox A | Very often (80–99%) | In 2 conditions |
| HNF4Ahepatocyte nuclear factor 4 alpha | Very often (80–99%) | In 2 conditions |
| MEN1menin 1 | Very often (80–99%) | In 1 condition |
| UCP2uncoupling protein 2 | Very often (80–99%) | In 1 condition |
| YY1YY1 transcription factor | Very often (80–99%) | In 1 condition |
| CDKN1Bcyclin dependent kinase inhibitor 1B | Often (30–79%) | In 1 condition |
| FOCADfocadhesin | Often (30–79%) | In 1 condition |
| MPImannose phosphate isomerase | Often (30–79%) | In 2 conditions |
| APPL1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | Sometimes (5–29%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| CELcarboxyl ester lipase | Sometimes (5–29%) | In 1 condition |
| INSinsulin | Sometimes (5–29%) | In 1 condition |
| KLF11KLF transcription factor 11 | Sometimes (5–29%) | In 1 condition |
| NEUROD1neuronal differentiation 1 | Sometimes (5–29%) | In 1 condition |
| PAX4paired box 4 | Sometimes (5–29%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Sometimes (5–29%) | In 1 condition |
| KDM6Alysine demethylase 6A | Rarely (1–4%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Rarely (1–4%) | In 1 condition |
| MAFAMAF bZIP transcription factor A | Not recorded | In 1 condition |
| SLC16A1solute carrier family 16 member 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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