Trait

Abnormality of mental function

Cognitive, psychiatric, or memory anomaly.

Also called: Abnormality of higher mental function
Body system: Abnormality of the nervous system

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page <- fromJSON(url)
page$trait$name

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15 genes linked to Abnormality of mental function

Changes in these genes cause rare conditions in which Abnormality of mental function is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ACAT1acetyl-CoA acetyltransferase 1	Very often (80–99%)	In 1 condition
ATP13A2ATPase cation transporting 13A2	Often (30–79%)	In 1 condition
SPG7SPG7 matrix AAA peptidase subunit, paraplegin	Often (30–79%)	In 1 condition
APPamyloid beta precursor protein	Sometimes (5–29%)	In 1 condition
GALTgalactose-1-phosphate uridylyltransferase	Sometimes (5–29%)	In 1 condition
MEN1menin 1	Sometimes (5–29%)	In 1 condition
PRNPprion protein (Kanno blood group)	Sometimes (5–29%)	In 1 condition
PSEN1presenilin 1	Sometimes (5–29%)	In 1 condition
PSEN2presenilin 2	Sometimes (5–29%)	In 1 condition
REEP2receptor accessory protein 2	Sometimes (5–29%)	In 1 condition
SORL1sortilin related receptor 1	Sometimes (5–29%)	In 1 condition
TOMM40translocase of outer mitochondrial membrane 40	Sometimes (5–29%)	In 1 condition
TREM2triggering receptor expressed on myeloid cells 2	Sometimes (5–29%)	In 1 condition
YY1YY1 transcription factor	Sometimes (5–29%)	In 1 condition
CRPPACDP-L-ribitol pyrophosphorylase A	Rarely (1–4%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal nervous system physiology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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