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Gene

MAP4K2

mitogen-activated protein kinase kinase kinase kinase 2

Summary

Cytogenetic location
11q13.1
Coordinates
Chromosome 11: 64,784,918–64,803,214 (GRCh38)
Exons
32 exons across 18.3 kb
Protein
820 amino acids
Also known as
GCK, BL44
Previous symbols
RAB8IP
MANE Select transcript
ENST00000294066.7NM_004579.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads MAP4K2 yet. The test sequences your whole genome, so your data includes it all the same.

How MAP4K2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 11, with a bracket where MAP4K2 sits. MAP4K2 and 39 genes near it on chromosome 11, from 64,294,066 to 65,294,065.Chromosome 1111q13.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2564.4 Mb64.6 Mb64.8 Mb65 Mb65.2 MbKCNK4: 64,291,302–64,300,031, forward strandCATSPERZ: 64,300,338–64,304,770, forward strandESRRA: 64,305,080–64,317,859, forward strandTRMT112: 64,316,460–64,318,086, reverse strandTRMT112PRDX5: 64,317,977–64,321,827, forward strandPRDX5CCDC88B: 64,340,197–64,357,534, forward strandCCDC88BRPS6KA4: 64,359,134–64,372,215, forward strandRPS6KA4SLC22A11: 64,555,632–64,572,875, forward strandSLC22A11SLC22A12: 64,590,641–64,602,353, forward strandSLC22A12NRXN2: 64,606,174–64,723,202, reverse strandNRXN2RASGRP2: 64,726,905–64,745,456, reverse strandRASGRP2PYGM: 64,746,389–64,759,990, reverse strandPYGMSF1: 64,764,605–64,778,802, reverse strandSF1MAP4K2: 64,784,918–64,803,214, reverse strandMAP4K2MEN1: 64,803,500–64,811,294, reverse strandMEN1CDC42BPG: 64,823,051–64,844,735, reverse strandCDC42BPGEHD1: 64,851,642–64,888,372, reverse strandEHD1ATG2A: 64,894,531–64,917,249, reverse strandATG2APPP2R5B: 64,917,553–64,934,480, forward strandPPP2R5BGPHA2: 64,934,471–64,935,894, reverse strandGPHA2MAJIN: 64,937,517–64,972,113, reverse strandMAJINBATF2: 64,987,945–64,997,018, reverse strandBATF2ARL2: 65,013,735–65,024,328, forward strandARL2ARL2-SNX15: 65,014,182–65,040,570, forward strandARL2-SNX15SNX15: 65,027,404–65,040,578, forward strandSNX15SAC3D1: 65,040,897–65,047,320, forward strandNAALADL1: 65,044,818–65,058,558, reverse strandCDCA5: 65,066,299–65,084,164, reverse strandZFPL1: 65,084,210–65,088,409, forward strandZFPL1CATSPERH: 65,084,974–65,089,375, reverse strandVPS51: 65,089,324–65,111,862, forward strandVPS51TM7SF2: 65,111,845–65,116,677, forward strandTM7SF2ZNHIT2: 65,116,403–65,117,701, reverse strandFAU: 65,120,182–65,122,221, reverse strandSYVN1: 65,121,780–65,146,912, reverse strandMRPL49: 65,122,183–65,127,371, forward strandSPDYC: 65,166,137–65,173,380, forward strandSPDYCCAPN1: 65,180,566–65,212,006, forward strandCAPN1POLA2: 65,261,835–65,305,959, forward strandPOLA2: 65,261,928–65,326,543, forward strandDiagram of MAP4K2: 32 exons on the reverse strand of chromosome 11Exon 32: 64,784,918–64,789,624, 4,707 basesExon 31: 64,789,730–64,789,785, 56 basesExon 30: 64,789,889–64,789,959, 71 basesExon 29: 64,790,188–64,790,274, 87 basesExon 28: 64,790,394–64,790,462, 69 basesExon 27: 64,791,909–64,792,086, 178 basesExon 26: 64,792,172–64,792,275, 104 basesExon 25: 64,792,364–64,792,422, 59 basesExon 24: 64,796,273–64,796,390, 118 basesExon 23: 64,796,493–64,796,553, 61 basesExon 22: 64,796,634–64,796,713, 80 basesExon 21: 64,796,809–64,796,893, 85 basesExon 20: 64,796,982–64,797,023, 42 basesExon 19: 64,797,104–64,797,192, 89 basesExon 18: 64,797,275–64,797,380, 106 basesExon 17: 64,797,501–64,797,534, 34 basesExon 16: 64,797,626–64,797,664, 39 basesExon 15: 64,798,794–64,798,837, 44 basesExon 14: 64,799,421–64,799,479, 59 basesExon 13: 64,799,605–64,799,683, 79 basesExon 12: 64,800,109–64,800,216, 108 basesExon 11: 64,800,311–64,800,392, 82 basesExon 10: 64,800,764–64,800,826, 63 basesExon 9: 64,800,900–64,801,031, 132 basesExon 8: 64,801,111–64,801,183, 73 basesExon 7: 64,801,579–64,801,621, 43 basesExon 6: 64,801,710–64,801,757, 48 basesExon 5: 64,802,066–64,802,121, 56 basesExon 4: 64,802,419–64,802,483, 65 basesExon 3: 64,802,563–64,802,653, 91 basesExon 2: 64,802,885–64,802,942, 58 basesExon 1: 64,803,054–64,803,214, 161 bases323025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.1 kb of the gene's 18.3 kb; 2,463 of those bases code for the protein.

Sequencing MAP4K2

1

position in MAP4K2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.3 kb of MAP4K2, introns included, not only the 7.1 kb of exons.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). MAP4K2 gene: mitogen-activated protein kinase kinase kinase kinase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/map4k2

Vancouver

Dante Labs. MAP4K2 gene: mitogen-activated protein kinase kinase kinase kinase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/map4k2

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