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Gene

STX16

syntaxin 16

Summary

Cytogenetic location
20q13.32
Coordinates
Chromosome 20: 58,651,283–58,679,526 (GRCh38)
Exons
9 exons across 28.2 kb
Protein
325 amino acids
Inheritance
Autosomal dominant
Also known as
hsyn16, SYN16, SYN-16
MANE Select transcript
ENST00000371141.8NM_001001433.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Pseudohypoparathyroidism & GNAS-Inactivation Disorders

    • PseudohypoparathyroidismAutosomal dominant

      Resistance to parathyroid hormone, and often to TSH and other hormones, causing low calcium and high phosphate, with or without Albright hereditary osteodystrophy.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Calcitriol, calcium and, where needed, levothyroxine or growth hormone treat the hormone resistance.

    • Disorder of GNAS inactivationAutosomal dominant

      Conditions caused by loss of GNAS function, including pseudopseudohypoparathyroidism and progressive osseous heteroplasia; which form develops depends on which parent the variant came from.

      • 3 GenCC submitters rate it definitive or strong

  • Thyroid Cancer

    • Parathyroid Gland Disorder

      A disease involving the parathyroid gland.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How STX16 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 20, with a bracket where STX16 sits. STX16 and 13 genes near it on chromosome 20, from 58,165,405 to 59,165,404.Chromosome 2020q13.32p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3358.2 Mb58.4 Mb58.6 Mb58.8 Mb59 MbANKRD60: 58,216,126–58,228,653, reverse strandANKRD60RAB22A: 58,309,706–58,367,507, forward strandRAB22AVAPB: 58,389,114–58,451,101, forward strandVAPBAPCDD1L: 58,457,632–58,515,399, reverse strandAPCDD1LSTX16: 58,651,283–58,679,526, forward strandSTX16STX16-NPEPL1: 58,651,434–58,715,410, forward strandSTX16-NPEPL1NPEPL1: 58,689,125–58,719,238, forward strandNPEPL1GNAS: 58,839,669–58,911,192, forward strandGNASNELFCD: 58,981,203–58,997,184, forward strandNELFCDCTSZ: 58,985,686–59,008,238, reverse strandCTSZTUBB1: 59,019,379–59,026,654, forward strandTUBB1ATP5F1E: 59,025,475–59,032,363, reverse strandATP5F1EPRELID3B: 59,033,092–59,042,897, reverse strandZNF831: 59,123,381–59,259,113, forward strandZNF831Diagram of STX16: 9 exons on the forward strand of chromosome 20Exon 1: 58,651,283–58,652,138, 856 basesExon 2: 58,659,623–58,659,634, 12 basesExon 3: 58,667,490–58,667,597, 108 basesExon 4: 58,667,987–58,668,127, 141 basesExon 5: 58,669,291–58,669,453, 163 basesExon 6: 58,670,512–58,670,603, 92 basesExon 7: 58,671,154–58,671,297, 144 basesExon 8: 58,673,631–58,673,711, 81 basesExon 9: 58,676,187–58,679,526, 3,340 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 28.2 kb; 978 of those bases code for the protein.

How a genome test reads STX16

2

positions in STX16 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (50%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

A whole genome covers all 28.2 kb of STX16, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). STX16 gene: syntaxin 16. Retrieved 16 October 2026, from https://dantelabs.com/genes/stx16

Vancouver

Dante Labs. STX16 gene: syntaxin 16 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/stx16

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