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Gene

ITGA7

integrin subunit alpha 7

Summary

Cytogenetic location
12q13.2
Coordinates
Chromosome 12: 55,684,568–55,707,904 (GRCh38)
Exons
25 exons across 23.3 kb
Protein
1,137 amino acids
MANE Select transcript
ENST00000257879.11NM_002206.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Muscular Dystrophies

    • Congenital muscular dystrophy

      A group of muscular dystrophies with onset at birth or in infancy, including dystroglycanopathies (such as FKRP, FKTN and POMT1/2-related forms).

      • 2 GenCC submitters rate it definitive or strong

How ITGA7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where ITGA7 sits. ITGA7 and 42 genes near it on chromosome 12, from 55,196,236 to 56,196,235.Chromosome 1212q13.2p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3355.2 Mb55.4 Mb55.6 Mb55.8 Mb56 MbOR10A7: 55,221,025–55,221,975, forward strandOR10A7OR6C74: 55,244,609–55,256,625, forward strandOR6C74OR6C6: 55,293,988–55,296,569, reverse strandOR6C6OR6C1: 55,314,343–55,322,364, forward strandOR6C1OR6C3: 55,330,043–55,332,687, forward strandOR6C3OR6C75: 55,362,975–55,369,279, forward strandOR6C75OR6C65: 55,400,529–55,401,467, forward strandOR6C65OR6C76: 55,426,254–55,427,192, forward strandOR6C76OR6C2: 55,444,069–55,453,347, forward strandOR6C2OR6C70: 55,469,200–55,470,138, reverse strandOR6C70OR6C68: 55,492,378–55,493,316, forward strandOR6C68OR6C4: 55,549,602–55,555,832, forward strandOR6C4OR2AP1: 55,572,468–55,575,612, forward strandOR2AP1OR10P1: 55,636,892–55,637,833, forward strandOR10P1TMT1B: 55,681,445–55,695,748, forward strandTMT1BITGA7: 55,684,568–55,707,904, reverse strandITGA7BLOC1S1: 55,715,911–55,720,087, forward strandBLOC1S1: 55,716,036–55,724,703, forward strandRDH5: 55,720,367–55,724,714, forward strandCD63: 55,723,511–55,737,367, reverse strandGDF11: 55,743,122–55,757,264, forward strandSARNP: 55,751,195–55,817,912, reverse strandSARNP: 55,757,275–55,827,546, reverse strandORMDL2: 55,818,034–55,824,097, forward strandORMDL2DNAJC14: 55,818,839–55,830,824, reverse strandDNAJC14MMP19: 55,835,433–55,843,005, reverse strandPYM1: 55,901,413–55,932,618, reverse strandPYM1DGKA: 55,927,319–55,954,027, forward strandDGKAPMEL: 55,954,104–55,973,317, reverse strandPMELCDK2: 55,966,781–55,972,789, forward strandCDK2RAB5B: 55,973,859–55,996,683, forward strandRAB5BSUOX: 55,996,855–56,006,641, forward strandSUOXIKZF4: 56,007,392–56,038,435, forward strandIKZF4RPS26: 56,041,351–56,044,697, forward strandRPS26ERBB3: 56,076,799–56,103,505, forward strandERBB3: 56,101,331–56,109,289, forward strandPA2G4: 56,104,349–56,116,329, forward strandPA2G4RPL41: 56,116,585–56,117,967, forward strandRPL41ZC3H10: 56,118,243–56,127,514, forward strandESYT1: 56,118,250–56,150,107, forward strandMYL6B: 56,151,966–56,159,647, forward strandMYL6: 56,158,322–56,166,572, forward strandMYL6SMARCC2: 56,162,359–56,189,587, reverse strandDiagram of ITGA7: 25 exons on the reverse strand of chromosome 12Exon 24: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 21: 2 known disease-causing sitesExon 20: 3 known disease-causing sitesExon 19: 2 known disease-causing sitesExon 18: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 15: 4 known disease-causing sitesExon 14: 1 known disease-causing siteExon 13: 3 known disease-causing sitesExon 12: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 3 known disease-causing sitesExon 9: 1 known disease-causing siteExon 7: 6 known disease-causing sitesExon 6: 1 known disease-causing siteExon 4: 4 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 1: 4 known disease-causing sitesExon 25: 55,684,568–55,685,288, 721 basesExon 24: 55,687,971–55,688,096, 126 basesExon 23: 55,688,202–55,688,300, 99 basesExon 22: 55,688,844–55,688,957, 114 basesExon 21: 55,692,844–55,692,975, 132 basesExon 20: 55,693,141–55,693,317, 177 basesExon 19: 55,694,021–55,694,123, 103 basesExon 18: 55,694,256–55,694,330, 75 basesExon 17: 55,694,443–55,694,522, 80 basesExon 16: 55,694,615–55,694,695, 81 basesExon 15: 55,694,778–55,694,970, 193 basesExon 14: 55,695,522–55,695,637, 116 basesExon 13: 55,696,283–55,696,432, 150 basesExon 12: 55,696,899–55,697,068, 170 basesExon 11: 55,697,216–55,697,277, 62 basesExon 10: 55,697,451–55,697,546, 96 basesExon 9: 55,697,695–55,697,822, 128 basesExon 8: 55,697,938–55,698,026, 89 basesExon 7: 55,698,383–55,698,576, 194 basesExon 6: 55,698,710–55,698,917, 208 basesExon 5: 55,699,870–55,699,989, 120 basesExon 4: 55,700,899–55,701,154, 256 basesExon 3: 55,702,872–55,702,951, 80 basesExon 2: 55,703,051–55,703,178, 128 basesExon 1: 55,707,477–55,707,904, 428 bases25201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 23.3 kb; 3,414 of those bases code for the protein.

How a genome test reads ITGA7

56

positions in ITGA7 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 23.3 kb of ITGA7, introns included, not only the 4.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ITGA7 gene: integrin subunit alpha 7. Retrieved 16 October 2026, from https://dantelabs.com/genes/itga7

Vancouver

Dante Labs. ITGA7 gene: integrin subunit alpha 7 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/itga7

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