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Gene

EIF2AK3

eukaryotic translation initiation factor 2 alpha kinase 3

Summary

Cytogenetic location
2p11.2
Coordinates
Chromosome 2: 88,556,741–88,627,464 (GRCh38)
Exons
17 exons across 70.7 kb
Protein
1,116 amino acids
Also known as
PEK, PERK
MANE Select transcript
ENST00000303236.9NM_004836.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads EIF2AK3 yet. The test sequences your whole genome, so your data includes it all the same.

How EIF2AK3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where EIF2AK3 sits. EIF2AK3 and 6 genes near it on chromosome 2, from 88,092,103 to 89,092,102.Chromosome 22p11.2p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.388.2 Mb88.4 Mb88.6 Mb88.8 Mb89 MbSMYD1: 88,067,773–88,113,384, forward strandSMYD1FABP1: 88,122,982–88,128,122, reverse strandFABP1THNSL2: 88,170,295–88,189,578, forward strandTHNSL2FOXI3: 88,444,826–88,452,693, reverse strandFOXI3SPMIP9: 88,524,619–88,529,591, forward strandSPMIP9EIF2AK3: 88,556,741–88,627,464, reverse strandEIF2AK3RPIA: 88,691,642–88,750,935, forward strandRPIADiagram of EIF2AK3: 17 exons on the reverse strand of chromosome 2Exon 17: 1 known disease-causing siteExon 15: 2 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 13: 13 known disease-causing sitesExon 12: 4 known disease-causing sitesExon 11: 1 known disease-causing siteExon 10: 4 known disease-causing sitesExon 9: 4 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 4 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 1: 3 known disease-causing sitesExon 17: 88,556,741–88,557,936, 1,196 basesExon 16: 88,558,917–88,558,979, 63 basesExon 15: 88,562,289–88,562,390, 102 basesExon 14: 88,570,874–88,571,041, 168 basesExon 13: 88,574,666–88,575,446, 781 basesExon 12: 88,576,554–88,576,703, 150 basesExon 11: 88,579,518–88,579,640, 123 basesExon 10: 88,583,430–88,583,542, 113 basesExon 9: 88,585,841–88,586,061, 221 basesExon 8: 88,587,982–88,588,104, 123 basesExon 7: 88,588,761–88,588,901, 141 basesExon 6: 88,590,443–88,590,605, 163 basesExon 5: 88,590,818–88,591,052, 235 basesExon 4: 88,593,272–88,593,405, 134 basesExon 3: 88,595,469–88,595,663, 195 basesExon 2: 88,613,724–88,613,853, 130 basesExon 1: 88,626,967–88,627,464, 498 bases171510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 70.7 kb; 3,351 of those bases code for the protein.

How a genome test reads EIF2AK3

55

positions in EIF2AK3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 70.7 kb of EIF2AK3, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). EIF2AK3 gene: eukaryotic translation initiation factor 2 alpha kinase 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/eif2ak3

Vancouver

Dante Labs. EIF2AK3 gene: eukaryotic translation initiation factor 2 alpha kinase 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/eif2ak3

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