Skip to content
Use your HSA or FSA funds

Gene

MAP3K20

mitogen-activated protein kinase kinase kinase 20

Summary

Cytogenetic location
2q31.1
Coordinates
Chromosome 2: 173,075,846–173,268,015 (GRCh38)
Exons
20 exons across 192.2 kb
Protein
800 amino acids
Also known as
MLTKalpha, MLTKbeta, ZAK, MLTK, MLK7, MRK
MANE Select transcript
ENST00000375213.8NM_016653.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Myopathies

    • Centronuclear myopathy (including X-linked myotubular myopathy)

      Congenital myopathies with centrally placed nuclei in muscle fibers, caused by MTM1, DNM2, BIN1 and other genes; the X-linked myotubular form (MTM1) is often severe in boys.

      • ClinGen rates the link strong
      • 2 GenCC submitters rate it definitive or strong

How MAP3K20 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where MAP3K20 sits. MAP3K20 and 2 genes near it on chromosome 2, from 172,671,931 to 173,671,930.Chromosome 22q31.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3172.8 Mb173 Mb173.2 Mb173.4 Mb173.6 MbRAPGEF4: 172,735,274–173,054,364, forward strandRAPGEF4MAP3K20: 173,075,846–173,268,015, forward strandMAP3K20CDCA7: 173,354,818–173,368,997, forward strandCDCA7Diagram of MAP3K20: 20 exons on the forward strand of chromosome 2Exon 7: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 1: 173,075,846–173,076,002, 157 basesExon 2: 173,090,998–173,091,190, 193 basesExon 3: 173,169,805–173,169,892, 88 basesExon 4: 173,182,854–173,182,955, 102 basesExon 5: 173,187,558–173,187,623, 66 basesExon 6: 173,190,895–173,190,923, 29 basesExon 7: 173,191,040–173,191,177, 138 basesExon 8: 173,198,026–173,198,112, 87 basesExon 9: 173,203,796–173,203,870, 75 basesExon 10: 173,209,729–173,209,835, 107 basesExon 11: 173,217,115–173,217,250, 136 basesExon 12: 173,229,689–173,229,733, 45 basesExon 13: 173,232,192–173,232,222, 31 basesExon 14: 173,232,320–173,232,459, 140 basesExon 15: 173,238,373–173,238,435, 63 basesExon 16: 173,239,404–173,239,496, 93 basesExon 17: 173,258,699–173,258,815, 117 basesExon 18: 173,261,063–173,261,137, 75 basesExon 19: 173,263,745–173,263,895, 151 basesExon 20: 173,266,050–173,268,015, 1,966 bases151015205′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.9 kb of the gene's 192.2 kb; 2,403 of those bases code for the protein.

How a genome test reads MAP3K20

2

positions in MAP3K20 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 192.2 kb of MAP3K20, introns included, not only the 3.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MAP3K20 gene: mitogen-activated protein kinase kinase kinase 20. Retrieved 17 October 2026, from https://dantelabs.com/genes/map3k20

Vancouver

Dante Labs. MAP3K20 gene: mitogen-activated protein kinase kinase kinase 20 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/map3k20

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test