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Gene

DNM2

dynamin 2

Summary

Cytogenetic location
19p13.2
Coordinates
Chromosome 19: 10,718,079–10,831,903 (GRCh38)
Exons
21 exons across 113.8 kb
Protein
870 amino acids
Also known as
DYNII, DYN2, CMTDIB, CMTDI1, DI-CMTB, CMT2M
MANE Select transcript
ENST00000389253.9NM_001005361.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Myopathies

    • Centronuclear myopathy (including X-linked myotubular myopathy)

      Congenital myopathies with centrally placed nuclei in muscle fibers, caused by MTM1, DNM2, BIN1 and other genes; the X-linked myotubular form (MTM1) is often severe in boys.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

Broader groupings

  • Charcot-Marie-Tooth Disease

    • One of 62 genes linked to it

      A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

How DNM2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 19, with a bracket where DNM2 sits. DNM2 and 32 genes near it on chromosome 19, from 10,274,991 to 11,274,990.Chromosome 1919p13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4310.4 Mb10.6 Mb10.8 Mb11 Mb11.2 MbICAM1: 10,271,093–10,286,617, forward strandICAM4: 10,286,946–10,288,522, forward strandICAM5: 10,289,940–10,296,778, forward strandZGLP1: 10,304,803–10,309,880, reverse strandFDX2-ZGLP1: 10,305,427–10,316,009, reverse strandFDX2: 10,309,898–10,316,026, reverse strandFDX2: 10,315,471–10,320,678, reverse strandRAVER1: 10,316,212–10,333,548, reverse strandRAVER1ICAM3: 10,333,776–10,339,847, reverse strandICAM3TYK2: 10,350,528–10,380,608, reverse strandTYK2CDC37: 10,391,090–10,420,224, reverse strandCDC37PDE4A: 10,416,773–10,469,816, forward strandPDE4AKEAP1: 10,484,512–10,503,558, reverse strandKEAP1S1PR5: 10,512,742–10,517,981, reverse strandS1PR5ATG4D: 10,543,533–10,553,556, forward strandATG4DKRI1: 10,553,085–10,566,031, reverse strandKRI1CDKN2D: 10,566,460–10,569,059, reverse strandCDKN2DAP1M2: 10,569,431–10,587,317, reverse strandAP1M2SLC44A2: 10,602,457–10,644,559, forward strandSLC44A2ILF3: 10,654,261–10,692,415, forward strandILF3QTRT1: 10,701,430–10,713,747, forward strandQTRT1DNM2: 10,718,079–10,831,903, forward strandDNM2TMED1: 10,832,067–10,836,330, reverse strandTMED1C19orf38: 10,836,567–10,869,796, forward strandC19orf38CARM1: 10,871,447–10,923,081, forward strandCARM1YIPF2: 10,918,919–10,928,704, reverse strandYIPF2TIMM29: 10,928,716–10,933,535, forward strandTIMM29SMARCA4: 10,960,824–11,079,426, forward strandSMARCA4LDLR: 11,089,418–11,133,830, forward strandLDLRSPC24: 11,131,419–11,155,815, reverse strandSPC24KANK2: 11,164,264–11,197,945, reverse strandKANK2DOCK6: 11,199,295–11,262,533, reverse strandDOCK6ANGPTL8: 11,237,502–11,245,478, forward strandANGPTL8Diagram of DNM2: 21 exons on the forward strand of chromosome 19Exon 8: 8 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 15: 4 known disease-causing sitesExon 16: 3 known disease-causing sitesExon 17: 8 known disease-causing sitesExon 18: 2 known disease-causing sitesExon 1: 10,718,079–10,718,403, 325 basesExon 2: 10,759,738–10,759,811, 74 basesExon 3: 10,772,479–10,772,628, 150 basesExon 4: 10,775,703–10,775,906, 204 basesExon 5: 10,777,118–10,777,216, 99 basesExon 6: 10,782,960–10,783,120, 161 basesExon 7: 10,786,564–10,786,706, 143 basesExon 8: 10,793,720–10,793,855, 136 bases. 3 variants with a page in exon 8. List themExon 9: 10,795,372–10,795,439, 68 basesExon 10: 10,797,380–10,797,518, 139 basesExon 11: 10,798,486–10,798,572, 87 bases. 1 variant with a page in exon 11. List themExon 12: 10,802,288–10,802,358, 71 basesExon 13: 10,805,916–10,805,967, 52 basesExon 14: 10,808,569–10,808,580, 12 basesExon 15: 10,812,264–10,812,377, 114 bases. 3 variants with a page in exon 15. List themExon 16: 10,819,980–10,820,089, 110 bases. 1 variant with a page in exon 16. List themExon 17: 10,823,788–10,823,899, 112 bases. 3 variants with a page in exon 17. List themExon 18: 10,825,057–10,825,221, 165 bases. 1 variant with a page in exon 18. List themExon 19: 10,829,036–10,829,268, 233 basesExon 20: 10,830,127–10,830,378, 252 basesExon 21: 10,830,978–10,831,903, 926 bases1215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.6 kb of the gene's 113.8 kb; 2,613 of those bases code for the protein.

How a genome test reads DNM2

28

positions in DNM2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 113.8 kb of DNM2, introns included, not only the 3.6 kb of exons.

Variants with a page (12)

The DNM2 variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
A618Tc.1852G>AExon 1710,823,858Pathogenic3 stars out of 4 reviewed by expert panel
D614Nc.1840G>AExon 1710,823,846Likely pathogenic3 stars out of 4 reviewed by expert panel
E368Kc.1102G>AExon 810,793,829Pathogenic3 stars out of 4 reviewed by expert panel
E560Kc.1678G>AExon 1610,819,986Likely pathogenic3 stars out of 4 reviewed by expert panel
E650Kc.1948G>AExon 1810,825,111Likely pathogenic3 stars out of 4 reviewed by expert panel
R369Qc.1106G>AExon 810,793,833Pathogenic3 stars out of 4 reviewed by expert panel
R369Wc.1105C>TExon 810,793,832Pathogenic3 stars out of 4 reviewed by expert panel
R465Wc.1393C>TExon 1110,798,543Pathogenic3 stars out of 4 reviewed by expert panel
R522Cc.1564C>TExon 1510,812,270Likely pathogenic3 stars out of 4 reviewed by expert panel
R522Hc.1565G>AExon 1510,812,271Pathogenic3 stars out of 4 reviewed by expert panel

See all 12 DNM2 variants →

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNM2 gene: dynamin 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/dnm2

Vancouver

Dante Labs. DNM2 gene: dynamin 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dnm2

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