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Gene

SGCG

sarcoglycan gamma

Summary

Cytogenetic location
13q12.12
Coordinates
Chromosome 13: 23,180,979–23,325,162 (GRCh38)
Exons
8 exons across 144.2 kb
Protein
291 amino acids
Also known as
SCARMD2, DAGA4, SCG3, DMDA, TYPE, A4, MGC130048
Previous symbols
DMDA1, MAM, LGMD2C
MANE Select transcript
ENST00000218867.4NM_000231.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Dilated Cardiomyopathy

    • Enlargement and weakening of the left ventricle not explained by coronary artery or valve disease; inherited forms involve TTN, LMNA, RBM20, FLNC, BAG3, DSP, MYH7, TNNT2, DES, PLN and many other genes, and include Barth syndrome and the Emery-Dreifuss muscular dystrophies.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing a genetic cause supports earlier heart monitoring and family screening, and for genes with a high arrhythmia risk such as LMNA, FLNC and RBM20 it informs decisions about rhythm monitoring and implantable defibrillators.

  • Limb-Girdle Muscular Dystrophy

    • Limb-girdle Muscular Dystrophy is defined as a collection of numerous subtypes with differing inheritance patterns (with diagnostic sufficiency being varied too). Carriers of variants related to the condition should seek guidance from a muscular-skeletal specialist for a definitive diagnosis.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong

How SGCG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 13, with a bracket where SGCG sits. SGCG and 3 genes near it on chromosome 13, from 22,753,071 to 23,753,070.Chromosome 1313q12.12p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3422.8 Mb23 Mb23.2 Mb23.4 Mb23.6 MbSGCG: 23,180,979–23,325,162, forward strandSGCGSACS: 23,288,689–23,433,763, reverse strandSACSTNFRSF19: 23,570,194–23,676,105, forward strandTNFRSF19MIPEP: 23,730,000–23,889,448, reverse strandMIPEPDiagram of SGCG: 8 exons on the forward strand of chromosome 13Exon 2: 18 known disease-causing sitesExon 3: 11 known disease-causing sitesExon 4: 10 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 6: 9 known disease-causing sitesExon 7: 10 known disease-causing sitesExon 8: 14 known disease-causing sitesExon 1: 23,180,979–23,181,075, 97 basesExon 2: 23,203,695–23,203,889, 195 bases. 4 variants with a page in exon 2. List themExon 3: 23,234,611–23,234,712, 102 basesExon 4: 23,250,630–23,250,717, 88 basesExon 5: 23,279,359–23,279,478, 120 basesExon 6: 23,295,415–23,295,487, 73 bases. 2 variants with a page in exon 6. List themExon 7: 23,320,637–23,320,760, 124 basesExon 8: 23,324,368–23,325,162, 795 bases. 2 variants with a page in exon 8. List them123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 144.2 kb; 876 of those bases code for the protein.

How a genome test reads SGCG

96

positions in SGCG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 144.2 kb of SGCG, introns included, not only the 1.6 kb of exons.

Variants with a page (10)

The SGCG variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
c.195_195+3delExon 223,203,888Pathogenic3 stars out of 4 reviewed by expert panel
c.579-2A>GIntron 623,320,635Pathogenic3 stars out of 4 reviewed by expert panel
c.703-1G>CIntron 723,324,367Likely pathogenic3 stars out of 4 reviewed by expert panel
C283Yc.848G>AExon 823,324,513Pathogenic3 stars out of 4 reviewed by expert panel
E176Xc.526G>TExon 623,295,435Pathogenic3 stars out of 4 reviewed by expert panel
E263Kc.787G>AExon 823,324,452Pathogenic3 stars out of 4 reviewed by expert panel
F175Lfs*20c.525delExon 623,295,429Pathogenic3 stars out of 4 reviewed by expert panel
G30Wfs*30c.87dupExon 223,203,780Pathogenic3 stars out of 4 reviewed by expert panel
L53Pc.158T>CExon 223,203,852Likely pathogenic3 stars out of 4 reviewed by expert panel
R34Pc.101G>CExon 223,203,795Likely pathogenic3 stars out of 4 reviewed by expert panel

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SGCG gene: sarcoglycan gamma. Retrieved 16 October 2026, from https://dantelabs.com/genes/sgcg

Vancouver

Dante Labs. SGCG gene: sarcoglycan gamma [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/sgcg

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