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Gene

SYNE2

spectrin repeat containing nuclear envelope protein 2

Summary

Cytogenetic location
14q23.2
Coordinates
Chromosome 14: 63,853,004–64,226,433 (GRCh38)
Exons
116 exons across 373.4 kb
Protein
6,907 amino acids
Also known as
SYNE-2, DKFZP434H2235, Nesprin-2, NUANCE, NUA, KIAA1011, Nesp2
MANE Select transcript
ENST00000555002.6NM_182914.3
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SYNE2 yet. The test sequences your whole genome, so your data includes it all the same.

How SYNE2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where SYNE2 sits. SYNE2 and 10 genes near it on chromosome 14, from 63,479,574 to 64,599,863.Chromosome 1414q23.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3363.6 Mb63.8 Mb64 Mb64.2 Mb64.4 MbPPP2R5E: 63,368,861–63,543,410, reverse strandPPP2R5EWDR89: 63,581,588–63,642,080, reverse strandWDR89SGPP1: 63,684,201–63,728,336, reverse strandSGPP1SYNE2: 63,853,004–64,226,433, forward strandSYNE2ESR2: 64,084,232–64,338,112, reverse strandESR2MTHFD1: 64,388,031–64,463,457, forward strandMTHFD1ZBTB25: 64,430,818–64,505,232, reverse strandZBTB25AKAP5: 64,465,275–64,474,503, forward strandAKAP5ZBTB1: 64,502,152–64,533,690, forward strandZBTB1HSPA2: 64,535,905–64,546,173, forward strandHSPA2PPP1R36: 64,549,890–64,590,096, forward strandPPP1R36Diagram of SYNE2: 116 exons on the forward strand of chromosome 14Exon 10: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 30: 1 known disease-causing siteExon 44: 1 known disease-causing siteExon 48: 2 known disease-causing sitesExon 84: 1 known disease-causing siteExon 111: 1 known disease-causing siteExon 1: 63,853,004–63,853,143, 140 basesExon 2: 63,909,098–63,909,227, 130 basesExon 3: 63,940,614–63,940,675, 62 basesExon 4: 63,941,695–63,941,790, 96 basesExon 5: 63,941,885–63,941,962, 78 basesExon 6: 63,942,051–63,942,143, 93 basesExon 7: 63,949,825–63,950,006, 182 basesExon 8: 63,954,719–63,954,915, 197 basesExon 9: 63,961,525–63,961,625, 101 basesExon 10: 63,963,899–63,964,000, 102 basesExon 11: 63,967,709–63,967,846, 138 basesExon 12: 63,976,563–63,976,727, 165 basesExon 13: 63,977,905–63,978,017, 113 basesExon 14: 63,978,852–63,979,014, 163 basesExon 15: 63,980,654–63,980,732, 79 basesExon 16: 63,980,986–63,981,173, 188 basesExon 17: 63,982,630–63,982,794, 165 basesExon 18: 63,983,737–63,983,886, 150 basesExon 19: 63,986,456–63,986,617, 162 basesExon 20: 63,990,411–63,990,569, 159 basesExon 21: 63,990,942–63,991,115, 174 basesExon 22: 63,993,835–63,993,969, 135 basesExon 23: 63,995,044–63,995,202, 159 basesExon 24: 63,996,947–63,997,158, 212 basesExon 25: 63,997,301–63,997,391, 91 basesExon 26: 63,998,219–63,998,328, 110 basesExon 27: 63,998,914–63,999,040, 127 basesExon 28: 64,000,562–64,000,719, 158 basesExon 29: 64,001,934–64,002,081, 148 basesExon 30: 64,002,720–64,003,330, 611 basesExon 31: 64,007,043–64,007,222, 180 basesExon 32: 64,009,966–64,010,116, 151 basesExon 33: 64,016,473–64,016,631, 159 basesExon 34: 64,017,595–64,017,756, 162 basesExon 35: 64,019,992–64,020,093, 102 basesExon 36: 64,021,315–64,021,515, 201 basesExon 37: 64,021,857–64,022,028, 172 basesExon 38: 64,022,751–64,022,863, 113 basesExon 39: 64,024,257–64,024,459, 203 basesExon 40: 64,024,912–64,025,031, 120 basesExon 41: 64,025,130–64,025,421, 292 basesExon 42: 64,026,579–64,026,730, 152 basesExon 43: 64,027,484–64,027,793, 310 basesExon 44: 64,029,895–64,030,059, 165 basesExon 45: 64,031,016–64,031,357, 342 basesExon 46: 64,048,000–64,048,155, 156 basesExon 47: 64,049,611–64,049,876, 266 basesExon 48: 64,051,557–64,053,657, 2,101 basesExon 49: 64,055,944–64,056,266, 323 basesExon 50: 64,062,751–64,062,895, 145 basesExon 51: 64,065,432–64,065,650, 219 basesExon 52: 64,070,645–64,070,910, 266 basesExon 53: 64,073,968–64,074,136, 169 basesExon 54: 64,075,945–64,076,100, 156 basesExon 55: 64,078,466–64,078,606, 141 basesExon 56: 64,080,456–64,080,638, 183 basesExon 57: 64,081,443–64,081,580, 138 basesExon 58: 64,087,671–64,087,856, 186 basesExon 59: 64,089,574–64,089,696, 123 basesExon 60: 64,090,866–64,091,048, 183 basesExon 61: 64,093,349–64,093,480, 132 basesExon 62: 64,097,949–64,098,146, 198 basesExon 63: 64,098,747–64,098,821, 75 basesExon 64: 64,101,932–64,102,042, 111 basesExon 65: 64,107,491–64,107,607, 117 basesExon 66: 64,113,341–64,113,571, 231 basesExon 67: 64,119,427–64,119,609, 183 basesExon 68: 64,120,927–64,121,061, 135 basesExon 69: 64,122,012–64,122,133, 122 basesExon 70: 64,122,286–64,122,427, 142 basesExon 71: 64,125,079–64,125,210, 132 basesExon 72: 64,126,327–64,126,479, 153 basesExon 73: 64,126,598–64,126,807, 210 basesExon 74: 64,128,452–64,128,553, 102 basesExon 75: 64,129,782–64,129,901, 120 basesExon 76: 64,130,048–64,130,248, 201 basesExon 77: 64,132,265–64,132,438, 174 basesExon 78: 64,134,069–64,134,200, 132 basesExon 79: 64,137,787–64,137,983, 197 basesExon 80: 64,139,941–64,140,073, 133 basesExon 81: 64,141,341–64,141,523, 183 basesExon 82: 64,141,942–64,142,088, 147 basesExon 83: 64,143,772–64,143,948, 177 basesExon 84: 64,146,068–64,146,223, 156 basesExon 85: 64,152,564–64,152,716, 153 basesExon 86: 64,158,625–64,158,795, 171 basesExon 87: 64,159,312–64,159,442, 131 basesExon 88: 64,162,072–64,162,276, 205 basesExon 89: 64,163,402–64,163,581, 180 basesExon 90: 64,165,285–64,165,410, 126 basesExon 91: 64,167,233–64,167,387, 155 basesExon 92: 64,167,495–64,167,639, 145 basesExon 93: 64,168,877–64,168,971, 95 basesExon 94: 64,170,228–64,170,462, 235 basesExon 95: 64,174,944–64,175,138, 195 basesExon 96: 64,177,358–64,177,483, 126 basesExon 97: 64,186,424–64,186,579, 156 basesExon 98: 64,188,550–64,188,708, 159 basesExon 99: 64,190,071–64,190,237, 167 basesExon 100: 64,202,801–64,202,963, 163 basesExon 101: 64,208,758–64,208,945, 188 basesExon 102: 64,209,428–64,209,578, 151 basesExon 103: 64,209,942–64,210,124, 183 basesExon 104: 64,211,961–64,212,098, 138 basesExon 105: 64,212,811–64,213,005, 195 basesExon 106: 64,214,194–64,214,470, 277 basesExon 107: 64,215,286–64,215,354, 69 basesExon 108: 64,216,248–64,216,387, 140 basesExon 109: 64,218,398–64,218,512, 115 basesExon 110: 64,219,208–64,219,410, 203 basesExon 111: 64,220,437–64,220,637, 201 basesExon 112: 64,221,576–64,221,704, 129 basesExon 113: 64,223,189–64,223,380, 192 basesExon 114: 64,224,461–64,224,547, 87 basesExon 115: 64,224,999–64,225,045, 47 basesExon 116: 64,225,319–64,226,433, 1,115 bases1204060801001165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 21.8 kb of the gene's 373.4 kb; 20,724 of those bases code for the protein.

How a genome test reads SYNE2

8

positions in SYNE2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 373.4 kb of SYNE2, introns included, not only the 21.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SYNE2 gene: spectrin repeat containing nuclear envelope protein 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/syne2

Vancouver

Dante Labs. SYNE2 gene: spectrin repeat containing nuclear envelope protein 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/syne2

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