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Gene

HACD1

3-hydroxyacyl-CoA dehydratase 1

Summary

Cytogenetic location
10p12.33
Coordinates
Chromosome 10: 17,589,032–17,617,374 (GRCh38)
Exons
7 exons across 28.3 kb
Protein
288 amino acids
Also known as
CAP
Previous symbols
PTPLA
MANE Select transcript
ENST00000361271.8NM_014241.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads HACD1 yet. The test sequences your whole genome, so your data includes it all the same.

How HACD1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where HACD1 sits. HACD1 and 8 genes near it on chromosome 10, from 17,103,203 to 18,103,202.Chromosome 1010p12.33p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.317.2 Mb17.4 Mb17.6 Mb17.8 Mb18 MbCUBN: 16,823,966–17,129,970, reverse strandCUBNTRDMT1: 17,137,336–17,202,054, reverse strandTRDMT1VIM: 17,228,241–17,237,595, forward strandVIMST8SIA6: 17,315,416–17,454,681, reverse strandST8SIA6HACD1: 17,589,032–17,617,374, reverse strandHACD1STAM: 17,644,124–17,735,901, forward strandSTAMTMEM236: 17,752,201–17,800,868, forward strandTMEM236MRC1: 17,809,014–17,911,607, forward strandMRC1SLC39A12: 17,951,825–18,043,292, forward strandSLC39A12Diagram of HACD1: 7 exons on the reverse strand of chromosome 10Exon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 7: 17,589,032–17,590,446, 1,415 basesExon 6: 17,594,205–17,594,383, 179 basesExon 5: 17,599,290–17,599,411, 122 basesExon 4: 17,603,560–17,603,648, 89 basesExon 3: 17,603,726–17,603,744, 19 basesExon 2: 17,603,930–17,604,047, 118 basesExon 1: 17,617,083–17,617,374, 292 bases7515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 28.3 kb; 867 of those bases code for the protein.

How a genome test reads HACD1

2

positions in HACD1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 28.3 kb of HACD1, introns included, not only the 2.2 kb of exons.

Traits linked to HACD1

The Human Phenotype Ontology lists these as features of the rare conditions HACD1 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HACD1 gene: 3-hydroxyacyl-CoA dehydratase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/hacd1

Vancouver

Dante Labs. HACD1 gene: 3-hydroxyacyl-CoA dehydratase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hacd1

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