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Trait

Low-grade fever

Mild fever that does not exceed 38.5 degrees centigrade.

HPO HP:0011134

Summary

Also called
Mild fever
Body system
Laboratory abnormality

12 genes linked to Low-grade fever

Changes in these genes cause rare conditions in which Low-grade fever is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
AK2adenylate kinase 2AlwaysIn 1 condition
ANKRD55ankyrin repeat domain 55Sometimes (5–29%)In 1 condition
CALRcalreticulinSometimes (5–29%)In 1 condition
CD247CD247 moleculeSometimes (5–29%)In 1 condition
IL2RAinterleukin 2 receptor subunit alphaSometimes (5–29%)In 1 condition
IL2RBinterleukin 2 receptor subunit betaSometimes (5–29%)In 1 condition
JAK2Janus kinase 2Sometimes (5–29%)In 1 condition
MPLMPL proto-oncogene, thrombopoietin receptorSometimes (5–29%)In 1 condition
PTPN2protein tyrosine phosphatase non-receptor type 2Sometimes (5–29%)In 1 condition
PTPN22protein tyrosine phosphatase non-receptor type 22Sometimes (5–29%)In 1 condition
STAT4signal transducer and activator of transcription 4Sometimes (5–29%)In 1 condition
TET2tet methylcytosine dioxygenase 2Sometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Fever

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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