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Gene

ARPC5

actin related protein 2/3 complex subunit 5

Summary

Cytogenetic location
1q25.3
Coordinates
Chromosome 1: 183,620,846–183,635,783 (GRCh38)
Exons
4 exons across 14.9 kb
Protein
151 amino acids
Also known as
p16-Arc, ARC16, dJ127C7.3
MANE Select transcript
ENST00000359856.11NM_005717.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • 1 GenCC submitter rates it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How ARPC5 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Stretches short reads find hard
    Chromosome 1, with a bracket where ARPC5 sits. ARPC5 and 9 genes near it on chromosome 1, from 183,128,315 to 184,128,314.Chromosome 11q25.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44183.2 Mb183.4 Mb183.6 Mb183.8 Mb184 MbLAMC1: 183,023,199–183,145,592, forward strandLAMC1LAMC2: 183,186,057–183,245,127, forward strandLAMC2NMNAT2: 183,244,571–183,418,421, reverse strandNMNAT2SMG7: 183,471,871–183,598,246, forward strandSMG7NCF2: 183,554,461–183,593,499, reverse strandNCF2ARPC5: 183,620,846–183,635,783, reverse strandARPC5RGL1: 183,636,066–183,928,532, forward strandRGL1APOBEC4: 183,646,275–183,653,316, reverse strandAPOBEC4COLGALT2: 183,929,854–184,037,777, reverse strandCOLGALT2TSEN15: 184,051,629–184,123,978, forward strandTSEN15Diagram of ARPC5: 4 exons on the reverse strand of chromosome 1Exon 4: 183,620,846–183,627,594, 6,749 basesExon 3: 183,630,461–183,630,637, 177 basesExon 2: 183,633,082–183,633,154, 73 basesExon 1: 183,635,517–183,635,783, 267 bases43215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 7.3 kb of the gene's 14.9 kb; 456 of those bases code for the protein.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ARPC5 gene: actin related protein 2/3 complex subunit 5. Retrieved 16 October 2026, from https://dantelabs.com/genes/arpc5

    Vancouver

    Dante Labs. ARPC5 gene: actin related protein 2/3 complex subunit 5 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/arpc5

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