Trait
Permanent enlargement of the airways of the lungs
Clinical name: Bronchiectasis
Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.
Summary
- Body system
- Abnormality of the respiratory system
Reference genomeGRCh38hg38
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Read the genes linked to Permanent enlargement of the airways of the lungs, and the rest of your genome, with one test.
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Get my Genome Test188 genes linked to Permanent enlargement of the airways of the lungs
Changes in these genes cause rare conditions in which Permanent enlargement of the airways of the lungs is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARHGEF1Rho guanine nucleotide exchange factor 1 | Always | In 1 condition |
| B2Mbeta-2-microglobulin | Always | In 1 condition |
| BRWD1bromodomain and WD repeat domain containing 1 | Always | In 2 conditions |
| CCNOcyclin O | Always | In 2 conditions |
| CFAP54cilia and flagella associated protein 54 | Always | In 1 condition |
| CFAP74cilia and flagella associated protein 74 | Always | In 2 conditions |
| CFTRCF transmembrane conductance regulator | Always | In 4 conditions |
| DNAAF1dynein axonemal assembly factor 1 | Always | In 2 conditions |
| DNAAF6dynein axonemal assembly factor 6 | Always | In 2 conditions |
| DNAH1dynein axonemal heavy chain 1 | Always | In 2 conditions |
| DNAH11dynein axonemal heavy chain 11 | Always | In 2 conditions |
| DNAJB13DnaJ heat shock protein family (Hsp40) member B13 | Always | In 2 conditions |
| DRC2dynein regulatory complex subunit 2 | Always | In 2 conditions |
| FOXJ1forkhead box J1 | Always | In 2 conditions |
| HYDINHYDIN axonemal central pair apparatus protein | Always | In 2 conditions |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 2 conditions |
| IL6STinterleukin 6 cytokine family signal transducer | Always | In 2 conditions |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| MALT1MALT1 paracaspase | Always | In 1 condition |
| MCIDASmulticiliate differentiation and DNA synthesis associated cell cycle protein | Always | In 2 conditions |
| MPEG1macrophage expressed 1 | Always | In 1 condition |
| NEK10NIMA related kinase 10 | Always | In 2 conditions |
| NME5NME/NM23 family member 5 | Always | In 2 conditions |
| ODAD1outer dynein arm docking complex subunit 1 | Always | In 2 conditions |
| ODAD4outer dynein arm docking complex subunit 4 | Always | In 2 conditions |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Always | In 1 condition |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| RASGRP1RAS guanyl releasing protein 1 | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| RSPH3radial spoke head 3 | Always | In 2 conditions |
| SCNN1Asodium channel epithelial 1 subunit alpha | Always | In 2 conditions |
| SCNN1Bsodium channel epithelial 1 subunit beta | Always | In 2 conditions |
| SCNN1Gsodium channel epithelial 1 subunit gamma | Always | In 2 conditions |
| SERPINA1serpin family A member 1 | Always | In 3 conditions |
| STK36serine/threonine kinase 36 | Always | In 2 conditions |
| STX3syntaxin 3 | Always | In 2 conditions |
| TAP2transporter 2, ATP binding cassette subfamily B member | Always | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Always | In 1 condition |
Show 148 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CCDC39coiled-coil domain 39 molecular ruler complex subunit | Very often (80–99%) | In 2 conditions |
| CEACAM3CEA cell adhesion molecule 3 | Very often (80–99%) | In 1 condition |
| CEACAM6CEA cell adhesion molecule 6 | Very often (80–99%) | In 1 condition |
| CLCA4chloride channel accessory 4 | Very often (80–99%) | In 1 condition |
| DCTN4dynactin subunit 4 | Very often (80–99%) | In 1 condition |
| DNAH5dynein axonemal heavy chain 5 | Very often (80–99%) | In 2 conditions |
| DNAI2dynein axonemal intermediate chain 2 | Very often (80–99%) | In 2 conditions |
| EDNRAendothelin receptor type A | Very often (80–99%) | In 1 condition |
| FCGR2AFc gamma receptor IIa | Very often (80–99%) | In 1 condition |
| GCLCglutamate-cysteine ligase catalytic subunit | Very often (80–99%) | In 1 condition |
| GSTM3glutathione S-transferase mu 3 | Very often (80–99%) | In 1 condition |
| HFEhomeostatic iron regulator | Very often (80–99%) | In 1 condition |
| HMOX1heme oxygenase 1 | Very often (80–99%) | In 1 condition |
| KCNN4potassium calcium-activated channel subfamily N member 4 | Very often (80–99%) | In 1 condition |
| MIFmacrophage migration inhibitory factor | Very often (80–99%) | In 1 condition |
| NCKAP1LNCK associated protein 1 like | Very often (80–99%) | In 1 condition |
| POLA1DNA polymerase alpha 1, catalytic subunit | Very often (80–99%) | In 1 condition |
| RSPH9radial spoke head component 9 | Very often (80–99%) | In 2 conditions |
| SLC11A1solute carrier family 11 member 1 | Very often (80–99%) | In 1 condition |
| SLC26A9solute carrier family 26 member 9 | Very often (80–99%) | In 1 condition |
| SLC6A14solute carrier family 6 member 14 | Very often (80–99%) | In 1 condition |
| SLC9A3solute carrier family 9 member A3 | Very often (80–99%) | In 1 condition |
| STX1Asyntaxin 1A | Very often (80–99%) | In 1 condition |
| TGFB1transforming growth factor beta 1 | Very often (80–99%) | In 2 conditions |
| WFDC2WAP four-disulfide core domain 2 | Very often (80–99%) | In 1 condition |
| ABCA3ATP binding cassette subfamily A member 3 | Often (30–79%) | In 1 condition |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Often (30–79%) | In 1 condition |
| ATP11AATPase phospholipid transporting 11A | Often (30–79%) | In 1 condition |
| BACH2BACH transcriptional regulator 2 | Often (30–79%) | In 1 condition |
| BTKBruton tyrosine kinase | Often (30–79%) | In 1 condition |
| C1QBcomplement C1q B chain | Often (30–79%) | In 1 condition |
| CARD10caspase recruitment domain family member 10 | Often (30–79%) | In 1 condition |
| CARMIL2capping protein regulator and myosin 1 linker 2 | Often (30–79%) | In 1 condition |
| CCDC40coiled-coil domain 40 molecular ruler complex subunit | Often (30–79%) | In 2 conditions |
| CFAP298cilia and flagella associated protein 298 | Often (30–79%) | In 2 conditions |
| DCLRE1CDNA cross-link repair 1C | Often (30–79%) | In 1 condition |
| DNAAF11dynein axonemal assembly factor 11 | Often (30–79%) | In 2 conditions |
| DNAAF4dynein axonemal assembly factor 4 | Often (30–79%) | In 2 conditions |
| DNAL1dynein axonemal light chain 1 | Often (30–79%) | In 2 conditions |
| DOCK8dedicator of cytokinesis 8 | Often (30–79%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Often (30–79%) | In 1 condition |
| DSPdesmoplakin | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 2 conditions |
| EMILIN1elastin microfibril interfacer 1 | Often (30–79%) | In 1 condition |
| FAM13Afamily with sequence similarity 13 member A | Often (30–79%) | In 1 condition |
| FNIP1folliculin interacting protein 1 | Often (30–79%) | In 1 condition |
| IL21Rinterleukin 21 receptor | Often (30–79%) | In 1 condition |
| LATlinker for activation of T cells | Often (30–79%) | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Often (30–79%) | In 1 condition |
| LRRC56leucine rich repeat containing 56 | Often (30–79%) | In 2 conditions |
| MAGT1magnesium transporter 1 | Often (30–79%) | In 1 condition |
| MUC5Bmucin 5B, oligomeric mucus/gel-forming | Often (30–79%) | In 1 condition |
| NFKB2nuclear factor kappa B subunit 2 | Often (30–79%) | In 1 condition |
| ODAD2outer dynein arm docking complex subunit 2 | Often (30–79%) | In 2 conditions |
| ODAD3outer dynein arm docking complex subunit 3 | Often (30–79%) | In 2 conditions |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 1 condition |
| PGM3phosphoglucomutase 3 | Often (30–79%) | In 2 conditions |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 3 conditions |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Often (30–79%) | In 3 conditions |
| POLD3DNA polymerase delta 3, accessory subunit | Often (30–79%) | In 1 condition |
| RAC2Rac family small GTPase 2 | Often (30–79%) | In 1 condition |
| RFX5regulatory factor X5 | Often (30–79%) | In 1 condition |
| RIPK1receptor interacting serine/threonine kinase 1 | Often (30–79%) | In 1 condition |
| RSPH1radial spoke head component 1 | Often (30–79%) | In 2 conditions |
| RSPH4Aradial spoke head component 4A | Often (30–79%) | In 2 conditions |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 1 condition |
| SFTPA1surfactant protein A1 | Often (30–79%) | In 1 condition |
| SFTPA2surfactant protein A2 | Often (30–79%) | In 1 condition |
| SFTPCsurfactant protein C | Often (30–79%) | In 2 conditions |
| SLC41A1solute carrier family 41 member 1 | Often (30–79%) | In 1 condition |
| SPAG1sperm associated antigen 1 | Often (30–79%) | In 2 conditions |
| STAT1signal transducer and activator of transcription 1 | Often (30–79%) | In 2 conditions |
| STAT3signal transducer and activator of transcription 3 | Often (30–79%) | In 1 condition |
| STK4serine/threonine kinase 4 | Often (30–79%) | In 1 condition |
| STN1STN1 subunit of CST complex | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 1 condition |
| TNFRSF9TNF receptor superfamily member 9 | Often (30–79%) | In 1 condition |
| TPP2tripeptidyl peptidase 2 | Often (30–79%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Often (30–79%) | In 1 condition |
| TTC12tetratricopeptide repeat domain 12 | Often (30–79%) | In 2 conditions |
| UNC119unc-119 lipid binding chaperone | Often (30–79%) | In 1 condition |
| WDR1WD repeat domain 1 | Often (30–79%) | In 1 condition |
| ZMYND10zinc finger MYND-type containing 10 | Often (30–79%) | In 2 conditions |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Sometimes (5–29%) | In 1 condition |
| ARL2BPARF like GTPase 2 binding protein | Sometimes (5–29%) | In 1 condition |
| BLNKB cell linker | Sometimes (5–29%) | In 1 condition |
| BTNL2butyrophilin like 2 | Sometimes (5–29%) | In 2 conditions |
| CARD11caspase recruitment domain family member 11 | Sometimes (5–29%) | In 1 condition |
| CD79ACD79a molecule | Sometimes (5–29%) | In 1 condition |
| CD79BCD79b molecule | Sometimes (5–29%) | In 1 condition |
| CFAP221cilia and flagella associated protein 221 | Sometimes (5–29%) | In 2 conditions |
| CFAP300cilia and flagella associated protein 300 | Sometimes (5–29%) | In 2 conditions |
| CLXNcalaxin | Sometimes (5–29%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Sometimes (5–29%) | In 2 conditions |
| CXCR4C-X-C motif chemokine receptor 4 | Sometimes (5–29%) | In 2 conditions |
| DAW1dynein assembly factor with WD repeats 1 | Sometimes (5–29%) | In 1 condition |
| DIAPH1diaphanous related formin 1 | Sometimes (5–29%) | In 2 conditions |
| DNAAF19dynein axonemal assembly factor 19 | Sometimes (5–29%) | In 2 conditions |
| DNAAF2dynein axonemal assembly factor 2 | Sometimes (5–29%) | In 1 condition |
| DNAAF3dynein axonemal assembly factor 3 | Sometimes (5–29%) | In 2 conditions |
| DNAAF5dynein axonemal assembly factor 5 | Sometimes (5–29%) | In 1 condition |
| DNAH7dynein axonemal heavy chain 7 | Sometimes (5–29%) | In 1 condition |
| DNAH9dynein axonemal heavy chain 9 | Sometimes (5–29%) | In 1 condition |
| DNAI1dynein axonemal intermediate chain 1 | Sometimes (5–29%) | In 2 conditions |
| DRC1dynein regulatory complex subunit 1 | Sometimes (5–29%) | In 2 conditions |
| DRC4dynein regulatory complex subunit 4 | Sometimes (5–29%) | In 2 conditions |
| FBLN5fibulin 5 | Sometimes (5–29%) | In 1 condition |
| GAS2L2growth arrest specific 2 like 2 | Sometimes (5–29%) | In 2 conditions |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 2 conditions |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Sometimes (5–29%) | In 1 condition |
| IGHMimmunoglobulin heavy constant mu | Sometimes (5–29%) | In 2 conditions |
| IGKCimmunoglobulin kappa constant | Sometimes (5–29%) | In 1 condition |
| IGLL1immunoglobulin lambda like polypeptide 1 | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| LRRC8Aleucine rich repeat containing 8 VRAC subunit A | Sometimes (5–29%) | In 1 condition |
| NBNnibrin | Sometimes (5–29%) | In 1 condition |
| NDUFA6NADH:ubiquinone oxidoreductase subunit A6 | Sometimes (5–29%) | In 1 condition |
| NFKB1nuclear factor kappa B subunit 1 | Sometimes (5–29%) | In 1 condition |
| NME8NME/NM23 family member 8 | Sometimes (5–29%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Sometimes (5–29%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Sometimes (5–29%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| RIN2Ras and Rab interactor 2 | Sometimes (5–29%) | In 1 condition |
| RPGRretinitis pigmentosa GTPase regulator | Sometimes (5–29%) | In 1 condition |
| SASH3SAM and SH3 domain containing 3 | Sometimes (5–29%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Sometimes (5–29%) | In 1 condition |
| SLC34A2solute carrier family 34 member 2 | Sometimes (5–29%) | In 1 condition |
| SLF2SMC5/6 complex localization factor 2 | Sometimes (5–29%) | In 1 condition |
| SPEF2sperm flagellar and cilia associated 2 | Sometimes (5–29%) | In 1 condition |
| SPI1Spi-1 proto-oncogene | Sometimes (5–29%) | In 1 condition |
| SYKspleen associated tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| TCF3transcription factor 3 | Sometimes (5–29%) | In 1 condition |
| ATMATM serine/threonine kinase | Not recorded | In 1 condition |
| BLMBLM RecQ like helicase | Not recorded | In 1 condition |
| CD19CD19 molecule | Not recorded | In 1 condition |
| CD8ACD8 subunit alpha | Not recorded | In 1 condition |
| CR2complement C3d receptor 2 | Not recorded | In 1 condition |
| DNMT3BDNA methyltransferase 3 beta | Not recorded | In 1 condition |
| FOXN1forkhead box N1 | Not recorded | In 1 condition |
| ICOSinducible T cell costimulator | Not recorded | In 2 conditions |
| IRF8interferon regulatory factor 8 | Not recorded | In 1 condition |
| IRF9interferon regulatory factor 9 | Not recorded | In 1 condition |
| TAP1transporter 1, ATP binding cassette subfamily B member | Not recorded | In 1 condition |
| TNFRSF13BTNF receptor superfamily member 13B | Not recorded | In 1 condition |
| TNFRSF13CTNF receptor superfamily member 13C | Not recorded | In 1 condition |
| TP73tumor protein p73 | Not recorded | In 1 condition |
| ZNF341zinc finger protein 341 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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From $449Free shipping · Results in 6–8 weeks