Trait

Chronic infection

Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.

HPO HP:0031035

Body system: Abnormality of the immune system

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21 genes linked to Chronic infection

Changes in these genes cause rare conditions in which Chronic infection is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
BCORBCL6 corepressor	Often (30–79%)	In 1 condition
FIP1L1factor interacting with PAPOLA and CPSF1	Often (30–79%)	In 1 condition
IRF2BP2interferon regulatory factor 2 binding protein 2	Often (30–79%)	In 1 condition
NABP1nucleic acid binding protein 1	Often (30–79%)	In 1 condition
NPM1nucleophosmin 1	Often (30–79%)	In 1 condition
NUMA1nuclear mitotic apparatus protein 1	Often (30–79%)	In 1 condition
PMLPML nuclear body scaffold	Often (30–79%)	In 1 condition
PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha	Often (30–79%)	In 1 condition
RARAretinoic acid receptor alpha	Often (30–79%)	In 1 condition
STAT3signal transducer and activator of transcription 3	Often (30–79%)	In 1 condition
STAT5Bsignal transducer and activator of transcription 5B	Often (30–79%)	In 1 condition
TBL1XR1TBL1X/Y related 1	Often (30–79%)	In 1 condition
ZBTB16zinc finger and BTB domain containing 16	Often (30–79%)	In 1 condition
HBBhemoglobin subunit beta	Sometimes (5–29%)	In 2 conditions
RPS14ribosomal protein S14	Sometimes (5–29%)	In 1 condition
SF3B1splicing factor 3b subunit 1	Sometimes (5–29%)	In 1 condition
TET2tet methylcytosine dioxygenase 2	Sometimes (5–29%)	In 1 condition
BCHEbutyrylcholinesterase	Rarely (1–4%)	In 1 condition
CLCN7Cl-/H+ antiporter 7	Rarely (1–4%)	In 1 condition
PLEKHM1pleckstrin homology and RUN domain containing M1	Rarely (1–4%)	In 1 condition
TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Rarely (1–4%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Unusual infection

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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