Trait
Amyloid deposition
Pathologic deposits of specific fibrillar protein aggregates with distinct microscopic properties, particularly affinity for the dye Congo red with typical birefringence.
Summary
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Get my Genome Test18 genes linked to Amyloid deposition
Changes in these genes cause rare conditions in which Amyloid deposition is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APOA1apolipoprotein A1 | Always | In 1 condition |
| LYZlysozyme | Always | In 1 condition |
| TTRtransthyretin | Always | In 1 condition |
| SAA1serum amyloid A1 | Very often (80–99%) | In 1 condition |
| CST3cystatin C | Often (30–79%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 2 conditions |
| ASXL1ASXL transcriptional regulator 1 | Rarely (1–4%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Rarely (1–4%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Rarely (1–4%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Rarely (1–4%) | In 1 condition |
| CCND1cyclin D1 | Not recorded | In 1 condition |
| GPR35G protein-coupled receptor 35 | Not recorded | In 1 condition |
| LIG4DNA ligase 4 | Not recorded | In 1 condition |
| MST1macrophage stimulating 1 | Not recorded | In 1 condition |
| NLRP1NLR family pyrin domain containing 1 | Not recorded | In 1 condition |
| SEMA4Dsemaphorin 4D | Not recorded | In 1 condition |
| TCF4transcription factor 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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