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Gene

KRT74

keratin 74

Summary

Cytogenetic location
12q13.13
Coordinates
Chromosome 12: 52,565,782–52,573,843 (GRCh38)
Exons
9 exons across 8.1 kb
Protein
529 amino acids
Inheritance
Autosomal dominant
Also known as
K6IRS4, KRT5C, KRT6IRS4
MANE Select transcript
ENST00000305620.3NM_175053.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How KRT74 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where KRT74 sits. KRT74 and 31 genes near it on chromosome 12, from 52,069,813 to 53,069,812.Chromosome 1212q13.13p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3352.2 Mb52.4 Mb52.6 Mb52.8 Mb53 MbATG101: 52,069,246–52,077,495, forward strandATG101SMIM41: 52,079,704–52,108,255, forward strandSMIM41KRT80: 52,168,996–52,192,311, reverse strandKRT80KRT7: 52,232,520–52,252,186, forward strandKRT7KRT86: 52,249,300–52,309,163, forward strandKRT86KRT81: 52,285,913–52,291,534, reverse strandKRT81KRT83: 52,314,301–52,321,398, reverse strandKRT83KRT85: 52,360,006–52,367,481, reverse strandKRT85KRT84: 52,377,812–52,385,652, reverse strandKRT84KRT82: 52,393,931–52,406,335, reverse strandKRT82KRT75: 52,424,070–52,434,380, reverse strandKRT75KRT6B: 52,446,651–52,452,154, reverse strandKRT6BKRT6C: 52,468,516–52,473,805, reverse strandKRT6CKRT6A: 52,487,176–52,493,265, reverse strandKRT6AKRT5: 52,514,575–52,520,530, reverse strandKRT5KRT71: 52,543,909–52,553,145, reverse strandKRT71KRT74: 52,565,782–52,573,843, reverse strandKRT74KRT72: 52,585,589–52,601,538, reverse strandKRT72KRT73: 52,607,570–52,618,559, reverse strandKRT73KRT2: 52,644,558–52,652,211, reverse strandKRT2KRT1: 52,674,736–52,680,407, reverse strandKRT1KRT77: 52,689,626–52,703,524, reverse strandKRT77KRT76: 52,768,155–52,777,345, reverse strandKRT76KRT3: 52,789,685–52,796,117, reverse strandKRT3KRT4: 52,806,549–52,814,116, reverse strandKRT4KRT79: 52,821,408–52,834,312, reverse strandKRT79KRT78: 52,837,804–52,849,092, reverse strandKRT78KRT8: 52,897,182–52,949,954, reverse strandKRT8KRT18: 52,945,688–52,952,911, forward strandKRT18EIF4B: 53,006,263–53,042,230, forward strandEIF4BTNS2: 53,046,969–53,064,621, forward strandTNS2SPRYD3: 53,064,316–53,079,414, reverse strandSPRYD3Diagram of KRT74: 9 exons on the reverse strand of chromosome 12Exon 5: 1 known disease-causing siteExon 9: 52,565,782–52,567,168, 1,387 basesExon 8: 52,567,659–52,567,693, 35 basesExon 7: 52,568,169–52,568,389, 221 basesExon 6: 52,569,859–52,569,984, 126 basesExon 5: 52,570,669–52,570,833, 165 basesExon 4: 52,571,359–52,571,454, 96 basesExon 3: 52,571,944–52,572,004, 61 basesExon 2: 52,572,453–52,572,667, 215 basesExon 1: 52,573,307–52,573,843, 537 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 8.1 kb; 1,590 of those bases code for the protein.

How a genome test reads KRT74

1

position in KRT74 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8.1 kb of KRT74, introns included, not only the 2.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KRT74 gene: keratin 74. Retrieved 16 October 2026, from https://dantelabs.com/genes/krt74

Vancouver

Dante Labs. KRT74 gene: keratin 74 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/krt74

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