Gene
DLX4
distal-less homeobox 4
- HGNC 2917↗(opens in a new tab)
- Ensembl gene ENSG00000108813↗(opens in a new tab)
- NCBI Gene 1748↗(opens in a new tab)
Summary
- Cytogenetic location
- 17q21.33
- Coordinates
- Chromosome 17: 49,969,190–49,974,959 (GRCh38)
- Exons
- 3 exons across 5.8 kb
- Protein
- 240 amino acids
- Also known as
- DLX8, BP1
- Previous symbols
- DLX7, DLX9
- MANE Select transcript
- ENST00000240306.5NM_138281.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How DLX4 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2 kb of the gene's 5.8 kb; 723 of those bases code for the protein.
Traits linked to DLX4
The Human Phenotype Ontology lists these as features of the rare conditions DLX4 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Both sided cleft lip
- Euryblepharon
- Eyelids stay open
- Lower eyelid folded out
- Right and left cleft palate
- Sparse eyebrow
- Abnormality of tooth eruption
- Bulbous nose
Show 15 more traits
- Cleft of the mouth
- Cleft palate
- Eye folds
- High frontal hairline
- Hole in roof of mouth
- Midface retrusion
- Missing lateral incisor
- One sided cleft palate
- Sparse eyelashes
- Upward slanting of the opening between the eyelids
- Velopharyngeal incompetence
- Abnormal number of permanent teeth
- Bad bite
- Peg-shaped maxillary lateral incisors
- Decreased size of maxilla
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). DLX4 gene: distal-less homeobox 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/dlx4
Dante Labs. DLX4 gene: distal-less homeobox 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dlx4
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