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Gene

LPAR6

lysophosphatidic acid receptor 6

Summary

Cytogenetic location
13q14.2
Coordinates
Chromosome 13: 48,411,138–48,413,113 (GRCh38)
Exons
1 exon across 2 kb
Protein
344 amino acids
Inheritance
Autosomal recessive
Also known as
P2Y5
Previous symbols
P2RY5
MANE Select transcript
ENST00000620633.5NM_001162498.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Hypotrichosis, Woolly Hair and Monilethrix

    • Autosomal recessive woolly hair 1Autosomal recessive

      Tightly curled, often sparse hair, related to the LIPH/LPAR6 pathway.

      • 1 GenCC submitter rates it definitive or strong
    • Hereditary hypotrichosis

      Sparse or absent scalp and body hair from childhood, including the LIPH- and LPAR6-related forms.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How LPAR6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 13, with a bracket where LPAR6 sits. LPAR6 and 7 genes near it on chromosome 13, from 47,912,126 to 48,912,125.Chromosome 1313q14.2p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3448 Mb48.2 Mb48.4 Mb48.6 Mb48.8 MbSUCLA2: 47,745,736–48,037,968, reverse strandSUCLA2MED4: 48,001,823–48,095,150, reverse strandMED4NUDT15: 48,037,514–48,054,196, forward strandNUDT15ITM2B: 48,232,612–48,270,357, forward strandITM2BRB1: 48,303,710–48,599,436, forward strandRB1LPAR6: 48,411,138–48,413,113, reverse strandLPAR6RCBTB2: 48,488,858–48,536,006, reverse strandRCBTB2CYSLTR2: 48,653,709–48,711,227, forward strandCYSLTR2Diagram of LPAR6: one exon on the reverse strand of chromosome 13Exon 1: 18 known disease-causing sitesExon 1: 48,411,138–48,413,113, 1,976 bases15′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 2 kb; 1,035 of those bases code for the protein.

How a genome test reads LPAR6

18

positions in LPAR6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 2 kb of LPAR6, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LPAR6 gene: lysophosphatidic acid receptor 6. Retrieved 16 October 2026, from https://dantelabs.com/genes/lpar6

Vancouver

Dante Labs. LPAR6 gene: lysophosphatidic acid receptor 6 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lpar6

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