Skip to content
Use your HSA or FSA funds

Gene

CRIPT

CXXC repeat containing interactor of PDZ3 domain

Summary

Cytogenetic location
2p21
Coordinates
Chromosome 2: 46,617,215–46,630,176 (GRCh38)
Exons
5 exons across 13 kb
Protein
101 amino acids
Inheritance
Autosomal recessive
Also known as
HSPC139
MANE Select transcript
ENST00000238892.4NM_014171.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rothmund-Thomson Syndrome

    • Autosomal recessive

      A genodermatosis with poikiloderma, sparse hair, small stature, skeletal abnormalities and, in type 2 (RECQL4), an increased risk of osteosarcoma and skin cancer.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Awareness of bone pain or swelling as possible signs of osteosarcoma, skin checks and sun protection; carriers have no expected health effects.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How CRIPT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where CRIPT sits. CRIPT and 11 genes near it on chromosome 2, from 46,123,696 to 47,123,695.Chromosome 22p21p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.346.2 Mb46.4 Mb46.6 Mb46.8 Mb47 MbPRKCE: 45,651,096–46,187,990, forward strandPRKCEEPAS1: 46,293,667–46,386,702, forward strandEPAS1TMEM247: 46,479,565–46,484,425, forward strandTMEM247ATP6V1E2: 46,490,750–46,543,287, reverse strandATP6V1E2RHOQ: 46,541,806–46,602,046, forward strandRHOQPIGF: 46,580,937–46,617,067, reverse strandPIGFCRIPT: 46,617,215–46,630,176, forward strandCRIPTSOCS5: 46,698,423–46,781,466, forward strandSOCS5MCFD2: 46,895,793–46,941,855, reverse strandMCFD2TTC7A: 46,915,869–47,076,137, forward strandTTC7ASTPG4: 47,045,538–47,155,308, reverse strandSTPG4: 47,065,941–47,176,511, reverse strandDiagram of CRIPT: 5 exons on the forward strand of chromosome 2Exon 1: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 1: 46,617,215–46,617,298, 84 basesExon 2: 46,618,773–46,618,838, 66 basesExon 3: 46,619,627–46,619,681, 55 basesExon 4: 46,623,764–46,623,867, 104 basesExon 5: 46,624,163–46,630,176, 6,014 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.3 kb of the gene's 13 kb; 306 of those bases code for the protein.

How a genome test reads CRIPT

6

positions in CRIPT where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13 kb of CRIPT, introns included, not only the 6.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CRIPT gene: CXXC repeat containing interactor of PDZ3 domain. Retrieved 16 October 2026, from https://dantelabs.com/genes/cript

Vancouver

Dante Labs. CRIPT gene: CXXC repeat containing interactor of PDZ3 domain [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cript

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test