Gene
RPL21
ribosomal protein L21
- HGNC 10313↗(opens in a new tab)
- Ensembl gene ENSG00000122026↗(opens in a new tab)
- NCBI Gene 6144↗(opens in a new tab)
Summary
- Cytogenetic location
- 13q12.2
- Coordinates
- Chromosome 13: 27,251,558–27,256,568 (GRCh38)
- Exons
- 6 exons across 5 kb
- Protein
- 160 amino acids
- Also known as
- L21, FLJ27458, MGC71252, MGC104274, MGC104275, DKFZp686C06101, eL21
- MANE Select transcript
- ENST00000311549.11NM_000982.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Hereditary Hypotrichosis, Woolly Hair and Monilethrix
- Hereditary hypotrichosis
Sparse or absent scalp and body hair from childhood, including the LIPH- and LPAR6-related forms.
- 2 GenCC submitters rate it definitive or strong
How RPL21 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 0.6 kb of the gene's 5 kb; 483 of those bases code for the protein.
Genes linked to the same conditions
- APCDD1APC down-regulated 1Shares 1 condition
- C3orf52chromosome 3 open reading frame 52Shares 1 condition
- CDH3cadherin 3Shares 1 condition
- CDSNcorneodesmosinShares 1 condition
- DSG4desmoglein 4Shares 1 condition
- HRHR lysine demethylase and nuclear receptor corepressorShares 1 condition
- LIPHlipase HShares 1 condition
- LPAR6lysophosphatidic acid receptor 6Shares 1 condition
- LSSlanosterol synthaseShares 1 condition
- SNRPEsmall nuclear ribonucleoprotein polypeptide EShares 1 condition
Traits linked to RPL21
The Human Phenotype Ontology lists these as features of the rare conditions RPL21 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). RPL21 gene: ribosomal protein L21. Retrieved 17 October 2026, from https://dantelabs.com/genes/rpl21
Dante Labs. RPL21 gene: ribosomal protein L21 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rpl21
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