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Gene

HECW2

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

Summary

Cytogenetic location
2q32.3
Coordinates
Chromosome 2: 196,194,072–196,593,554 (GRCh38)
Exons
29 exons across 399.5 kb
Protein
1,572 amino acids
Also known as
KIAA1301, NEDL2
MANE Select transcript
ENST00000644978.2NM_001348768.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HECW2 yet. The test sequences your whole genome, so your data includes it all the same.

How HECW2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where HECW2 sits. HECW2 and 7 genes near it on chromosome 2, from 195,794,589 to 196,993,037.Chromosome 22q32.3p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3195.8 Mb196 Mb196.2 Mb196.4 Mb196.6 Mb196.8 MbDNAH7: 195,737,524–196,068,848, reverse strandDNAH7STK17B: 196,133,559–196,176,503, reverse strandSTK17BHECW2: 196,194,072–196,593,554, reverse strandHECW2CCDC150: 196,639,554–196,763,490, forward strandCCDC150GTF3C3: 196,761,062–196,799,743, reverse strandGTF3C3C2orf66: 196,804,417–196,809,355, reverse strandC2orf66PGAP1: 196,833,004–196,927,796, reverse strandPGAP1ANKRD44: 196,967,017–197,311,173, reverse strandANKRD44Diagram of HECW2: 29 exons on the reverse strand of chromosome 2Exon 29: 1 known disease-causing siteExon 28: 5 known disease-causing sitesExon 27: 2 known disease-causing sitesExon 26: 5 known disease-causing sitesExon 23: 2 known disease-causing sitesExon 22: 1 known disease-causing siteExon 20: 7 known disease-causing sitesExon 13: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 4: 1 known disease-causing siteExon 29: 196,194,072–196,201,388, 7,317 basesExon 28: 196,215,865–196,215,977, 113 basesExon 27: 196,217,008–196,217,093, 86 basesExon 26: 196,220,039–196,220,153, 115 basesExon 25: 196,220,795–196,220,941, 147 basesExon 24: 196,222,211–196,222,340, 130 basesExon 23: 196,225,772–196,225,870, 99 basesExon 22: 196,228,102–196,228,254, 153 basesExon 21: 196,240,449–196,240,562, 114 basesExon 20: 196,242,084–196,242,204, 121 basesExon 19: 196,253,920–196,254,029, 110 basesExon 18: 196,257,823–196,257,906, 84 basesExon 17: 196,271,193–196,271,289, 97 basesExon 16: 196,274,021–196,274,123, 103 basesExon 15: 196,278,528–196,278,662, 135 basesExon 14: 196,292,565–196,292,750, 186 basesExon 13: 196,306,488–196,306,612, 125 basesExon 12: 196,307,130–196,307,233, 104 basesExon 11: 196,307,935–196,308,085, 151 basesExon 10: 196,317,274–196,317,369, 96 basesExon 9: 196,318,552–196,319,904, 1,353 basesExon 8: 196,320,339–196,320,439, 101 basesExon 7: 196,322,478–196,322,620, 143 basesExon 6: 196,324,980–196,325,149, 170 basesExon 5: 196,329,575–196,329,650, 76 basesExon 4: 196,334,424–196,334,518, 95 basesExon 3: 196,343,657–196,343,764, 108 basesExon 2: 196,433,132–196,433,458, 327 basesExon 1: 196,593,508–196,593,554, 47 bases2925201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12 kb of the gene's 399.5 kb; 4,719 of those bases code for the protein.

How a genome test reads HECW2

28

positions in HECW2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 399.5 kb of HECW2, introns included, not only the 12 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HECW2 gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/hecw2

Vancouver

Dante Labs. HECW2 gene: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hecw2

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