Gene
CDH3
cadherin 3
- HGNC 1762(opens in a new tab)
- Ensembl gene ENSG00000062038(opens in a new tab)
- NCBI Gene 1001(opens in a new tab)
Summary
- Cytogenetic location
- 16q22.1
- Coordinates
- Chromosome 16: 68,645,310–68,700,292 (GRCh38)
- Exons
- 16 exons across 55 kb
- Protein
- 829 amino acids
- Also known as
- CDHP, PCAD
- MANE Select transcript
- ENST00000264012.9NM_001793.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read CDH3, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated report relevant to this gene
Hereditary Hypotrichosis, Woolly Hair and Monilethrix
- Hereditary hypotrichosis
Sparse or absent scalp and body hair from childhood, including the LIPH- and LPAR6-related forms.
- 1 GenCC submitter rates it definitive or strong
How CDH3 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.5 kb of the gene's 55 kb; 2,490 of those bases code for the protein.
How a genome test reads CDH3
14
positions in CDH3 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 55 kb of CDH3, introns included, not only the 4.5 kb of exons.
Traits linked to CDH3
The Human Phenotype Ontology lists these as features of the rare conditions CDH3 can cause. Each trait's page lists the other genes linked to it.
Abnormality of limbs
- Cleft hand
- Finger syndactyly
- 3-4 finger cutaneous syndactyly
- Abnormal shape of limb bone
- Split hand
- Webbed 1st-4th finger
- Webbed 2nd-3rd fingers
- Webbed 3rd-4th toes
Show 2 more traits
Abnormality of head or neck
- Sparse scalp hair
- Abnormality of dental shape
- Absence of a tooth
- Absent eyebrow
- Decreased size of tooth
- Dental cavities
- Widely spaced teeth
- Sparse eyebrow
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). CDH3 gene: cadherin 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/cdh3
Dante Labs. CDH3 gene: cadherin 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cdh3
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks