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Gene

LIPH

lipase H

Summary

Cytogenetic location
3q27.2
Coordinates
Chromosome 3: 185,506,262–185,552,588 (GRCh38)
Exons
10 exons across 46.3 kb
Protein
451 amino acids
Also known as
mPA-PLA1, PLA1B, mPA-PLA1alpha, LPDLR
MANE Select transcript
ENST00000296252.9NM_139248.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

How LIPH is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where LIPH sits. LIPH and 8 genes near it on chromosome 3, from 185,029,425 to 186,029,424.Chromosome 33q27.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29185.2 Mb185.4 Mb185.6 Mb185.8 Mb186 MbVPS8: 184,812,113–185,054,009, forward strandVPS8C3orf70: 185,076,838–185,153,654, reverse strandC3orf70EHHADH: 185,190,624–185,281,990, reverse strandEHHADHMAP3K13: 185,282,941–185,489,094, forward strandMAP3K13TMEM41A: 185,475,950–185,499,096, reverse strandTMEM41ALIPH: 185,506,262–185,552,588, reverse strandLIPHSENP2: 185,582,496–185,633,551, forward strandSENP2IGF2BP2: 185,643,130–185,825,309, reverse strandIGF2BP2TRA2B: 185,914,558–185,938,103, reverse strandTRA2BDiagram of LIPH: 10 exons on the reverse strand of chromosome 3Exon 8: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 2: 3 known disease-causing sitesExon 10: 185,506,262–185,508,877, 2,616 basesExon 9: 185,511,524–185,511,697, 174 basesExon 8: 185,514,410–185,514,521, 112 basesExon 7: 185,517,067–185,517,162, 96 basesExon 6: 185,519,142–185,519,309, 168 basesExon 5: 185,524,071–185,524,160, 90 basesExon 4: 185,527,484–185,527,585, 102 basesExon 3: 185,533,571–185,533,679, 109 basesExon 2: 185,534,765–185,535,132, 368 basesExon 1: 185,552,423–185,552,588, 166 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4 kb of the gene's 46.3 kb; 1,356 of those bases code for the protein.

How a genome test reads LIPH

7

positions in LIPH where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 46.3 kb of LIPH, introns included, not only the 4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LIPH gene: lipase H. Retrieved 16 October 2026, from https://dantelabs.com/genes/liph

Vancouver

Dante Labs. LIPH gene: lipase H [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/liph

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