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Gene

ST14

ST14 transmembrane serine protease matriptase

Summary

Cytogenetic location
11q24.3
Coordinates
Chromosome 11: 130,159,782–130,210,362 (GRCh38)
Exons
19 exons across 50.6 kb
Protein
855 amino acids
Inheritance
Autosomal recessive
Also known as
SNC19, HAI, MT-SP1, TMPRSS14, CAP3
Previous symbols
PRSS14
MANE Select transcript
ENST00000278742.6NM_021978.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Inherited Ichthyoses

    • Autosomal recessive congenital ichthyosisAutosomal recessive

      A group of recessive ichthyoses, including harlequin ichthyosis and lamellar ichthyosis, usually present at birth, often with a collodion membrane.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Early diagnosis guides neonatal care, emollient and keratolytic regimens, and heat-intolerance precautions.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ST14 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 11, with a bracket where ST14 sits. ST14 and 7 genes near it on chromosome 11, from 129,685,072 to 130,685,071.Chromosome 1111q24.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25129.8 Mb130 Mb130.2 Mb130.4 Mb130.6 MbTMEM45B: 129,815,786–129,862,079, forward strandTMEM45BNFRKB: 129,863,087–129,895,590, reverse strandNFRKBPRDM10: 129,899,706–130,002,860, reverse strandPRDM10APLP2: 130,068,147–130,144,811, forward strandAPLP2ST14: 130,159,782–130,210,362, forward strandST14ZBTB44: 130,226,677–130,314,917, reverse strandZBTB44ADAMTS8: 130,404,923–130,428,732, reverse strandADAMTS8ADAMTS15: 130,448,635–130,476,645, forward strandADAMTS15Diagram of ST14: 19 exons on the forward strand of chromosome 11Exon 1: 130,159,782–130,160,060, 279 basesExon 2: 130,188,114–130,188,273, 160 basesExon 3: 130,188,530–130,188,657, 128 basesExon 4: 130,188,869–130,188,939, 71 basesExon 5: 130,189,739–130,189,896, 158 basesExon 6: 130,190,113–130,190,148, 36 basesExon 7: 130,190,454–130,190,694, 241 basesExon 8: 130,194,149–130,194,288, 140 basesExon 9: 130,194,640–130,194,737, 98 basesExon 10: 130,196,339–130,196,448, 110 basesExon 11: 130,196,570–130,196,700, 131 basesExon 12: 130,197,841–130,197,945, 105 basesExon 13: 130,198,308–130,198,418, 111 basesExon 14: 130,198,508–130,198,621, 114 basesExon 15: 130,198,947–130,199,069, 123 basesExon 16: 130,199,951–130,200,137, 187 basesExon 17: 130,208,410–130,208,684, 275 basesExon 18: 130,209,442–130,209,578, 137 basesExon 19: 130,209,662–130,210,362, 701 bases151015195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.3 kb of the gene's 50.6 kb; 2,568 of those bases code for the protein.

How a genome test reads ST14

3

positions in ST14 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 50.6 kb of ST14, introns included, not only the 3.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ST14 gene: ST14 transmembrane serine protease matriptase. Retrieved 16 October 2026, from https://dantelabs.com/genes/st14

Vancouver

Dante Labs. ST14 gene: ST14 transmembrane serine protease matriptase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/st14

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