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Gene

ADAMTS18

ADAM metallopeptidase with thrombospondin type 1 motif 18

Summary

Cytogenetic location
16q23.1
Coordinates
Chromosome 16: 77,282,128–77,435,034 (GRCh38)
Exons
23 exons across 152.9 kb
Protein
1,221 amino acids
Previous symbols
ADAMTS21
MANE Select transcript
ENST00000282849.10NM_199355.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads ADAMTS18 yet. The test sequences your whole genome, so your data includes it all the same.

How ADAMTS18 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where ADAMTS18 sits. ADAMTS18 and 4 genes near it on chromosome 16, from 76,858,581 to 77,858,580.Chromosome 1616q23.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.377 Mb77.2 Mb77.4 Mb77.6 Mb77.8 MbMON1B: 77,190,835–77,202,398, forward strandMON1BSYCE1L: 77,199,400–77,213,215, forward strandSYCE1LADAMTS18: 77,282,128–77,435,034, reverse strandADAMTS18NUDT7: 77,722,474–77,776,042, forward strandNUDT7VAT1L: 77,788,527–77,980,107, forward strandVAT1LDiagram of ADAMTS18: 23 exons on the reverse strand of chromosome 16Exon 21: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 23: 77,282,128–77,284,071, 1,944 basesExon 22: 77,289,264–77,289,411, 148 basesExon 21: 77,291,266–77,291,478, 213 basesExon 20: 77,293,076–77,293,258, 183 basesExon 19: 77,294,923–77,295,127, 205 basesExon 18: 77,297,289–77,297,415, 127 basesExon 17: 77,300,263–77,300,404, 142 basesExon 16: 77,319,849–77,320,093, 245 basesExon 15: 77,321,079–77,321,202, 124 basesExon 14: 77,322,336–77,322,466, 131 basesExon 13: 77,325,866–77,326,038, 173 basesExon 12: 77,335,756–77,335,904, 149 basesExon 11: 77,341,704–77,341,799, 96 basesExon 10: 77,353,733–77,353,886, 154 basesExon 9: 77,355,940–77,356,077, 138 basesExon 8: 77,359,318–77,359,423, 106 basesExon 7: 77,362,105–77,362,264, 160 basesExon 6: 77,363,802–77,363,885, 84 basesExon 5: 77,364,188–77,364,381, 194 basesExon 4: 77,367,441–77,367,723, 283 basesExon 3: 77,431,295–77,431,611, 317 basesExon 2: 77,434,418–77,434,505, 88 basesExon 1: 77,434,606–77,435,034, 429 bases23201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 152.9 kb; 3,666 of those bases code for the protein.

Sequencing ADAMTS18

2Low

How hard ADAMTS18 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats2%
  • GC content13%
  • Reference coverage0%

6

positions in ADAMTS18 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 152.9 kb of ADAMTS18, introns included, not only the 5.8 kb of exons.

Traits linked to ADAMTS18

The Human Phenotype Ontology lists these as features of the rare conditions ADAMTS18 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). ADAMTS18 gene: ADAM metallopeptidase with thrombospondin type 1 motif 18. Retrieved 17 October 2026, from https://dantelabs.com/genes/adamts18

Vancouver

Dante Labs. ADAMTS18 gene: ADAM metallopeptidase with thrombospondin type 1 motif 18 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/adamts18

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