Gene
GLYCTK
glycerate kinase
- HGNC 24247↗(opens in a new tab)
- Ensembl gene ENSG00000168237↗(opens in a new tab)
- NCBI Gene 132158↗(opens in a new tab)
Summary
- Cytogenetic location
- 3p21.2
- Coordinates
- Chromosome 3: 52,287,828–52,295,257 (GRCh38)
- Exons
- 5 exons across 7.4 kb
- Protein
- 523 amino acids
- Also known as
- HBEBP4, HBEBP2
- MANE Select transcript
- ENST00000436784.7NM_145262.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads GLYCTK yet. The test sequences your whole genome, so your data includes it all the same.
How GLYCTK is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.8 kb of the gene's 7.4 kb; 1,572 of those bases code for the protein.
How a genome test reads GLYCTK
3
positions in GLYCTK where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 7.4 kb of GLYCTK, introns included, not only the 3.8 kb of exons.
Traits linked to GLYCTK
The Human Phenotype Ontology lists these as features of the rare conditions GLYCTK can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Encephalopathy
- Epilepsy
- Global developmental delay
- Progressive brain disease
- Brisk reflexes
- Decrease in size of the outer layer of the brain due to loss of brain cells
- Delayed CNS myelination
- Delayed speech and language development
Show 15 more traits
- Focal clonic seizure
- Grand mal seizures
- Intellectual disability
- Repeated seizures without recovery between them
- Tongue thrusting
- Autism spectrum disorder
- Brain degeneration
- Chorea
- Jerking
- Loss of consciousness
- Profound global developmental delay
- Severe global developmental delay
- Underdevelopment of part of brain called corpus callosum
- Hypsarrhythmia
- Increased reflexes
Laboratory abnormality
- Elevated circulating D-glyceric acid concentration
- Elevated CSF D-glyceric acid concentration
- Reduced hepatic D-glycerate kinase activity
- Abnormal circulating enzyme concentration or activity
- Metabolic acidosis
- Elevated blood glycine levels
- High urine glycine levels
- Increased circulating free fatty acid level
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). GLYCTK gene: glycerate kinase. Retrieved 17 October 2026, from https://dantelabs.com/genes/glyctk
Dante Labs. GLYCTK gene: glycerate kinase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/glyctk
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