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Gene

H1-4

H1.4 linker histone, cluster member

Summary

Cytogenetic location
6p22.2
Coordinates
Chromosome 6: 26,156,329–26,157,115 (GRCh38)
Exons
1 exon across 0.8 kb
Protein
219 amino acids
Also known as
H1.4, H1e, H1s-4
Previous symbols
H1F4, HIST1H1E
MANE Select transcript
ENST00000304218.6NM_005321.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 1 GenCC submitter rates it definitive or strong

    How H1-4 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome 6, with a bracket where H1-4 sits. H1-4 and 51 genes near it on chromosome 6, from 25,656,722 to 26,656,721.Chromosome 66p22.2p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2725.8 Mb26 Mb26.2 Mb26.4 Mb26.6 MbSCGN: 25,652,201–25,701,792, forward strandSCGN: 25,652,210–25,738,044, forward strandH2AC1: 25,723,397–25,726,562, reverse strandH2AC1H2BC1: 25,726,777–25,727,345, forward strandH2BC1SLC17A4: 25,753,300–25,783,316, forward strandSLC17A4SLC17A1: 25,781,532–25,832,067, reverse strandSLC17A1SLC17A3: 25,833,066–25,882,478, reverse strandSLC17A3SLC17A2: 25,906,892–25,930,815, reverse strandSLC17A2TRIM38: 25,962,693–25,991,231, forward strandTRIM38H1-1: 26,017,032–26,017,787, reverse strandH3C1: 26,020,451–26,021,487, forward strandH4C1: 26,021,649–26,022,847, forward strandH4C2: 26,025,802–26,027,283, reverse strandH3C2: 26,028,850–26,032,102, reverse strandH2AC4: 26,033,092–26,033,618, reverse strandH2AC4H2BC3: 26,042,771–26,043,713, reverse strandH2BC3H3C3: 26,045,384–26,045,869, forward strandH3C3H1-2: 26,054,760–26,056,470, reverse strandH1-2H2BC4: 26,067,392–26,124,016, reverse strandH2BC4HFE: 26,087,226–26,098,343, forward strandH4C3: 26,103,933–26,104,337, forward strandH4C3H1-6: 26,107,412–26,108,135, reverse strandH1-6H2AC6: 26,124,145–26,139,116, forward strandH2AC6H1-4: 26,156,329–26,157,115, forward strandH1-4H2BC5: 26,158,122–26,171,349, forward strandH2BC5H2BC6: 26,172,059–26,184,655, forward strandH2BC6H4C4: 26,188,710–26,189,112, reverse strandH4C4H3C4: 26,195,164–26,197,286, reverse strand: 26,195,595–26,199,293, reverse strandH2AC7: 26,198,784–26,199,293, reverse strandH2BC7: 26,199,516–26,199,988, forward strandH4C5: 26,204,610–26,205,021, forward strandH2BC8: 26,214,570–26,217,252, reverse strandH2AC8: 26,216,921–26,218,515, forward strandH3C6: 26,224,179–26,227,476, forward strandH1-3: 26,234,212–26,234,987, reverse strandH1-3H4C6: 26,240,393–26,240,793, forward strandH4C6H4C7: 26,246,611–26,246,996, reverse strandH4C7H3C7: 26,250,142–26,250,635, reverse strandH2BC9: 26,251,614–26,252,075, forward strandH3C8: 26,270,918–26,271,413, reverse strandH2BC10: 26,272,931–26,273,412, forward strandH4C8: 26,277,609–26,285,638, reverse strandH4C8BTN3A2: 26,365,159–26,382,797, forward strandBTN3A2BTN2A2: 26,383,091–26,394,880, forward strandBTN2A2BTN3A1: 26,402,237–26,415,216, forward strandBTN3A1BTN3A3: 26,440,452–26,453,422, forward strandBTN3A3BTN2A1: 26,457,904–26,476,621, forward strandBTN2A1BTN1A1: 26,500,303–26,510,425, forward strandBTN1A1HMGN4: 26,538,200–26,546,949, forward strandHMGN4ABT1: 26,596,928–26,600,739, forward strandABT1ZNF322: 26,634,383–26,659,759, reverse strandZNF322Diagram of H1-4: one exon on the forward strand of chromosome 6Exon 1: 16 known disease-causing sitesExon 1: 26,156,329–26,157,115, 787 bases15′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 0.8 kb of the gene's 0.8 kb; 660 of those bases code for the protein.

    How a genome test reads H1-4

    16

    positions in H1-4 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 0.8 kb of H1-4, introns included, not only the 0.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). H1-4 gene: H1.4 linker histone, cluster member. Retrieved 17 October 2026, from https://dantelabs.com/genes/h1-4

    Vancouver

    Dante Labs. H1-4 gene: H1.4 linker histone, cluster member [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/h1-4

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