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Gene

PLCB3

phospholipase C beta 3

Summary

Cytogenetic location
11q13.1
Coordinates
Chromosome 11: 64,251,530–64,267,923 (GRCh38)
Exons
31 exons across 16.4 kb
Protein
1,234 amino acids
MANE Select transcript
ENST00000279230.12NM_000932.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PLCB3 yet. The test sequences your whole genome, so your data includes it all the same.

How PLCB3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where PLCB3 sits. PLCB3 and 33 genes near it on chromosome 11, from 63,759,727 to 64,759,726.Chromosome 1111q13.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2563.8 Mb64 Mb64.2 Mb64.4 Mb64.6 MbRTN3: 63,681,444–63,759,909, forward strandRTN3ZFTA: 63,759,892–63,769,752, reverse strandZFTASPINDOC: 63,813,405–63,827,718, forward strandSPINDOCMARK2: 63,838,852–63,911,020, forward strandMARK2RCOR2: 63,910,992–63,919,787, reverse strandRCOR2NAA40: 63,938,669–63,957,324, forward strandNAA40COX8A: 63,974,579–63,976,543, forward strandCOX8AOTUB1: 63,985,853–64,001,811, forward strandOTUB1MACROD1: 63,998,553–64,166,501, reverse strandMACROD1FLRT1: 64,035,757–64,119,403, forward strandFLRT1STIP1: 64,185,272–64,204,549, forward strandFERMT3: 64,205,926–64,223,896, forward strandTRPT1: 64,223,799–64,226,823, reverse strandNUDT22: 64,225,941–64,230,686, forward strandDNAJC4: 64,230,158–64,234,286, forward strandVEGFB: 64,234,406–64,239,264, forward strandFKBP2: 64,241,003–64,244,583, forward strandFKBP2: 64,241,095–64,244,583, forward strandPPP1R14B: 64,244,478–64,246,956, reverse strandPPP1R14BPLCB3: 64,251,530–64,267,923, forward strandPLCB3BAD: 64,269,828–64,291,946, reverse strandGPR137: 64,270,062–64,290,690, forward strandGPR137KCNK4: 64,291,302–64,300,031, forward strandCATSPERZ: 64,300,338–64,304,770, forward strandESRRA: 64,305,080–64,317,859, forward strandESRRATRMT112: 64,316,460–64,318,086, reverse strandPRDX5: 64,317,977–64,321,827, forward strandCCDC88B: 64,340,197–64,357,534, forward strandCCDC88BRPS6KA4: 64,359,134–64,372,215, forward strandRPS6KA4SLC22A11: 64,555,632–64,572,875, forward strandSLC22A11SLC22A12: 64,590,641–64,602,353, forward strandSLC22A12NRXN2: 64,606,174–64,723,202, reverse strandNRXN2RASGRP2: 64,726,905–64,745,456, reverse strandRASGRP2PYGM: 64,746,389–64,759,990, reverse strandPYGMDiagram of PLCB3: 31 exons on the forward strand of chromosome 11Exon 22: 1 known disease-causing siteExon 1: 64,251,530–64,251,748, 219 basesExon 2: 64,254,415–64,254,492, 78 basesExon 3: 64,254,748–64,254,816, 69 basesExon 4: 64,254,898–64,255,038, 141 basesExon 5: 64,255,234–64,255,313, 80 basesExon 6: 64,255,396–64,255,449, 54 basesExon 7: 64,255,541–64,255,616, 76 basesExon 8: 64,255,721–64,255,821, 101 basesExon 9: 64,256,376–64,256,542, 167 basesExon 10: 64,256,618–64,256,764, 147 basesExon 11: 64,258,473–64,258,713, 241 basesExon 12: 64,258,885–64,258,969, 85 basesExon 13: 64,259,058–64,259,244, 187 basesExon 14: 64,260,029–64,260,234, 206 basesExon 15: 64,261,400–64,261,496, 97 basesExon 16: 64,261,581–64,261,665, 85 basesExon 17: 64,261,952–64,262,076, 125 basesExon 18: 64,262,407–64,262,561, 155 basesExon 19: 64,262,647–64,262,808, 162 basesExon 20: 64,263,498–64,263,597, 100 basesExon 21: 64,263,691–64,263,795, 105 basesExon 22: 64,264,021–64,264,112, 92 basesExon 23: 64,264,951–64,265,104, 154 basesExon 24: 64,265,192–64,265,227, 36 basesExon 25: 64,265,310–64,265,502, 193 basesExon 26: 64,265,886–64,266,039, 154 basesExon 27: 64,266,126–64,266,202, 77 basesExon 28: 64,266,315–64,266,404, 90 basesExon 29: 64,266,495–64,266,552, 58 basesExon 30: 64,267,185–64,267,271, 87 basesExon 31: 64,267,353–64,267,923, 571 bases124681012141618202224262830315′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 16.4 kb; 3,705 of those bases code for the protein.

How a genome test reads PLCB3

1

position in PLCB3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16.4 kb of PLCB3, introns included, not only the 4.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PLCB3 gene: phospholipase C beta 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/plcb3

Vancouver

Dante Labs. PLCB3 gene: phospholipase C beta 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/plcb3

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