Skip to content
Use your HSA or FSA funds

Gene

PCLO

piccolo presynaptic cytomatrix protein

Summary

Cytogenetic location
7q21.11
Coordinates
Chromosome 7: 82,754,012–83,162,884 (GRCh38)
Exons
25 exons across 408.9 kb
Protein
5,142 amino acids
Also known as
KIAA0559, DKFZp779G1236, ACZ
MANE Select transcript
ENST00000333891.14NM_033026.6
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PCLO yet. The test sequences your whole genome, so your data includes it all the same.

How PCLO is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where PCLO sits. PCLO and 2 genes near it on chromosome 7, from 82,345,139 to 83,571,757.Chromosome 77q21.11p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.382.4 Mb82.6 Mb82.8 Mb83 Mb83.2 Mb83.4 MbCACNA2D1: 81,946,444–82,444,194, reverse strandCACNA2D1PCLO: 82,754,012–83,162,884, reverse strandPCLOSEMA3E: 83,363,238–83,649,188, reverse strandSEMA3EDiagram of PCLO: 25 exons on the reverse strand of chromosome 7Exon 14: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 25: 82,754,012–82,758,715, 4,704 basesExon 24: 82,760,639–82,760,784, 146 basesExon 23: 82,761,359–82,761,493, 135 basesExon 22: 82,801,518–82,801,591, 74 basesExon 21: 82,805,688–82,805,829, 142 basesExon 20: 82,822,495–82,822,689, 195 basesExon 19: 82,824,236–82,824,416, 181 basesExon 18: 82,826,589–82,826,660, 72 basesExon 17: 82,827,873–82,827,966, 94 basesExon 16: 82,835,667–82,835,693, 27 basesExon 15: 82,838,218–82,838,342, 125 basesExon 14: 82,841,459–82,841,509, 51 basesExon 13: 82,845,271–82,845,485, 215 basesExon 12: 82,846,567–82,846,634, 68 basesExon 11: 82,847,139–82,847,247, 109 basesExon 10: 82,879,337–82,879,462, 126 basesExon 9: 82,902,651–82,902,741, 91 basesExon 8: 82,908,877–82,909,013, 137 basesExon 7: 82,914,686–82,916,873, 2,188 basesExon 6: 82,949,476–82,951,490, 2,015 basesExon 5: 82,951,856–82,956,935, 5,080 basesExon 4: 82,965,771–82,966,487, 717 basesExon 3: 83,134,250–83,135,656, 1,407 basesExon 2: 83,154,748–83,156,392, 1,645 basesExon 1: 83,162,345–83,162,884, 540 bases25201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 20.3 kb of the gene's 408.9 kb; 15,429 of those bases code for the protein.

How a genome test reads PCLO

3

positions in PCLO where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 408.9 kb of PCLO, introns included, not only the 20.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PCLO gene: piccolo presynaptic cytomatrix protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/pclo

Vancouver

Dante Labs. PCLO gene: piccolo presynaptic cytomatrix protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pclo

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test