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Gene

MAG

myelin associated glycoprotein

Summary

Cytogenetic location
19q13.1
Coordinates
Chromosome 19: 35,292,161–35,313,807 (GRCh38)
Exons
11 exons across 21.6 kb
Protein
626 amino acids
Inheritance
Autosomal recessive
Also known as
SIGLEC4A, SIGLEC-4A, S-MAG, SIGLEC4
Previous symbols
GMA
MANE Select transcript
ENST00000392213.8NM_002361.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Hereditary Spastic Paraplegia

    • Hereditary Spastic Paraplegia 75Autosomal recessive

      Any hereditary spastic paraplegia in which the cause of the disease is a mutation in the MAG gene.

      • 1 GenCC submitter rates it definitive or strong
    • Hereditary Spastic Paraplegia (All Types)

      One of 66 genes linked to it

      Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How MAG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where MAG sits. MAG and 44 genes near it on chromosome 19, from 34,802,984 to 35,802,983.Chromosome 1919q13.1p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4335 Mb35.2 Mb35.4 Mb35.6 Mb35.8 MbZNF30: 34,926,887–34,945,172, forward strandZNF30ZNF792: 34,956,167–34,964,293, reverse strandZNF792GRAMD1A: 34,994,537–35,027,406, forward strandGRAMD1ASCN1B: 35,030,444–35,040,455, forward strandSCN1BHPN: 35,040,506–35,066,592, forward strandHPN: 35,106,510–35,124,297, forward strandFXYD3: 35,115,521–35,125,653, forward strandLGI4: 35,124,507–35,142,451, reverse strandLGI4FXYD1: 35,133,987–35,143,109, forward strandFXYD1FXYD7: 35,143,148–35,154,303, forward strandFXYD7FXYD5: 35,154,440–35,171,796, forward strandFXYD5FAM187B: 35,224,800–35,228,739, reverse strandFAM187BLSR: 35,248,330–35,267,967, forward strandLSRUSF2: 35,268,485–35,279,821, forward strandUSF2HAMP: 35,280,716–35,285,146, forward strandHAMPMAG: 35,292,161–35,313,807, forward strandMAGCD22: 35,319,261–35,347,361, forward strandCD22FFAR1: 35,347,902–35,353,864, forward strandFFAR1FFAR3: 35,358,348–35,360,489, forward strandFFAR3GPR42: 35,371,068–35,372,962, forward strandGPR42FFAR2: 35,443,907–35,451,767, forward strandFFAR2KRTDAP: 35,487,324–35,495,558, reverse strandKRTDAPDMKN: 35,497,220–35,513,704, reverse strandDMKNSBSN: 35,523,367–35,528,351, reverse strandSBSNGAPDHS: 35,533,455–35,545,319, forward strandGAPDHSTMEM147: 35,545,600–35,547,527, forward strandATP4A: 35,549,339–35,563,658, reverse strandATP4APMIS2: 35,586,161–35,587,296, forward strandPMIS2HAUS5: 35,612,735–35,625,355, forward strandHAUS5RBM42: 35,628,989–35,638,927, forward strandRBM42ETV2: 35,641,730–35,644,871, forward strandETV2COX6B1: 35,648,230–35,662,890, forward strandCOX6B1UPK1A: 35,666,516–35,678,481, forward strandUPK1AZBTB32: 35,704,558–35,717,048, forward strandZBTB32KMT2B: 35,717,973–35,738,880, forward strandKMT2BIGFLR1: 35,738,798–35,742,459, reverse strandIGFLR1: 35,739,252–35,745,432, reverse strandU2AF1L4: 35,742,464–35,745,460, reverse strandPSENEN: 35,745,070–35,747,519, forward strand: 35,745,678–35,754,519, forward strandLIN37: 35,748,361–35,754,519, forward strandHSPB6: 35,754,566–35,758,079, reverse strandPROSER3: 35,758,143–35,771,398, forward strandARHGAP33: 35,774,532–35,788,822, forward strandPRODH2: 35,799,975–35,813,299, reverse strandPRODH2Diagram of MAG: 11 exons on the forward strand of chromosome 19Exon 4: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 35,292,161–35,292,204, 44 basesExon 2: 35,294,235–35,294,290, 56 basesExon 3: 35,295,386–35,295,454, 69 basesExon 4: 35,295,613–35,295,981, 369 basesExon 5: 35,299,554–35,299,850, 297 basesExon 6: 35,300,147–35,300,404, 258 basesExon 7: 35,302,448–35,302,708, 261 basesExon 8: 35,309,874–35,310,161, 288 basesExon 9: 35,310,547–35,310,643, 97 basesExon 10: 35,311,918–35,312,017, 100 basesExon 11: 35,313,290–35,313,807, 518 bases12345678910115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 21.6 kb; 1,881 of those bases code for the protein.

How a genome test reads MAG

10

positions in MAG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 21.6 kb of MAG, introns included, not only the 2.4 kb of exons.

Genes linked to the same conditions

Traits linked to MAG

The Human Phenotype Ontology lists these as features of the rare conditions MAG can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MAG gene: myelin associated glycoprotein. Retrieved 17 October 2026, from https://dantelabs.com/genes/mag

Vancouver

Dante Labs. MAG gene: myelin associated glycoprotein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mag

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