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Gene

USP7

ubiquitin specific peptidase 7

Summary

Cytogenetic location
16p13.2
Coordinates
Chromosome 16: 8,892,097–8,963,906 (GRCh38)
Exons
31 exons across 71.8 kb
Protein
1,102 amino acids
Previous symbols
HAUSP
MANE Select transcript
ENST00000344836.9NM_003470.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads USP7 yet. The test sequences your whole genome, so your data includes it all the same.

How USP7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where USP7 sits. USP7 and 8 genes near it on chromosome 16, from 8,428,002 to 9,428,001.Chromosome 1616p13.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.38.6 Mb8.8 Mb9 Mb9.2 Mb9.4 MbTMEM114: 8,537,605–8,590,511, reverse strandTMEM114METTL22: 8,621,655–8,665,132, forward strandMETTL22ABAT: 8,674,596–8,784,575, forward strandABATTMEM186: 8,778,233–8,797,763, reverse strandTMEM186PMM2: 8,788,823–8,862,534, forward strandPMM2CARHSP1: 8,852,942–8,870,941, reverse strandCARHSP1LITAFD: 8,875,704–8,885,353, forward strandLITAFDUSP7: 8,892,097–8,963,906, reverse strandUSP7HAPSTR1: 9,091,594–9,121,635, forward strandHAPSTR1Diagram of USP7: 31 exons on the reverse strand of chromosome 16Exon 29: 2 known disease-causing sitesExon 24: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 14: 2 known disease-causing sitesExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 31: 8,892,097–8,894,104, 2,008 basesExon 30: 8,894,550–8,894,640, 91 basesExon 29: 8,894,784–8,894,855, 72 basesExon 28: 8,895,031–8,895,150, 120 basesExon 27: 8,895,642–8,895,741, 100 basesExon 26: 8,896,999–8,897,099, 101 basesExon 25: 8,898,360–8,898,437, 78 basesExon 24: 8,898,531–8,898,639, 109 basesExon 23: 8,899,121–8,899,188, 68 basesExon 22: 8,899,604–8,899,757, 154 basesExon 21: 8,900,530–8,900,630, 101 basesExon 20: 8,900,990–8,901,057, 68 basesExon 19: 8,901,142–8,901,234, 93 basesExon 18: 8,902,082–8,902,187, 106 basesExon 17: 8,902,381–8,902,482, 102 basesExon 16: 8,903,268–8,903,402, 135 basesExon 15: 8,904,435–8,904,565, 131 basesExon 14: 8,905,187–8,905,331, 145 basesExon 13: 8,906,426–8,906,582, 157 basesExon 12: 8,908,341–8,908,450, 110 basesExon 11: 8,910,745–8,910,827, 83 basesExon 10: 8,915,254–8,915,344, 91 basesExon 9: 8,915,445–8,915,525, 81 basesExon 8: 8,916,502–8,916,556, 55 basesExon 7: 8,917,026–8,917,156, 131 basesExon 6: 8,919,031–8,919,139, 109 basesExon 5: 8,920,359–8,920,447, 89 basesExon 4: 8,921,157–8,921,295, 139 basesExon 3: 8,923,215–8,923,413, 199 basesExon 2: 8,930,293–8,930,397, 105 basesExon 1: 8,963,207–8,963,906, 700 bases312015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 71.8 kb; 3,309 of those bases code for the protein.

How a genome test reads USP7

17

positions in USP7 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 71.8 kb of USP7, introns included, not only the 5.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). USP7 gene: ubiquitin specific peptidase 7. Retrieved 17 October 2026, from https://dantelabs.com/genes/usp7

Vancouver

Dante Labs. USP7 gene: ubiquitin specific peptidase 7 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/usp7

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