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Gene

EGR2

early growth response 2

Summary

Cytogenetic location
10q21.3
Coordinates
Chromosome 10: 62,811,996–62,816,366 (GRCh38)
Exons
2 exons across 4.4 kb
Protein
476 amino acids
Previous symbols
KROX20
MANE Select transcript
ENST00000242480.4NM_000399.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Charcot-Marie-Tooth Disease

      • One of 62 genes linked to it

        A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong
        What knowing changes

        Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

    How EGR2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome 10, with a bracket where EGR2 sits. EGR2 and 5 genes near it on chromosome 10, from 62,314,181 to 63,314,180.Chromosome 1010q21.3p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.362.4 Mb62.6 Mb62.8 Mb63 Mb63.2 MbZNF365: 62,374,089–62,482,255, forward strandZNF365: 62,374,192–62,672,011, forward strandADO: 62,804,720–62,808,479, forward strandADOEGR2: 62,811,996–62,816,366, reverse strandEGR2NRBF2: 63,133,247–63,156,880, forward strandNRBF2JMJD1C: 63,167,221–63,521,850, reverse strandJMJD1CDiagram of EGR2: 2 exons on the reverse strand of chromosome 10Exon 2: 15 known disease-causing sitesExon 2: 62,811,996–62,814,468, 2,473 basesExon 1: 62,815,861–62,816,366, 506 bases215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3 kb of the gene's 4.4 kb; 1,431 of those bases code for the protein.

    How a genome test reads EGR2

    15

    positions in EGR2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 4.4 kb of EGR2, introns included, not only the 3 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). EGR2 gene: early growth response 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/egr2

    Vancouver

    Dante Labs. EGR2 gene: early growth response 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/egr2

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