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Gene

ANAPC1

anaphase promoting complex subunit 1

Summary

Cytogenetic location
2q13
Coordinates
Chromosome 2: 111,767,640–111,884,193 (GRCh38)
Exons
48 exons across 116.6 kb
Protein
1,944 amino acids
Inheritance
Autosomal recessive
Also known as
MCPR, TSG24, APC1
MANE Select transcript
ENST00000341068.8NM_022662.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rothmund-Thomson Syndrome

    • Autosomal recessive

      A genodermatosis with poikiloderma, sparse hair, small stature, skeletal abnormalities and, in type 2 (RECQL4), an increased risk of osteosarcoma and skin cancer.

      • ClinGen rates the link moderate
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Awareness of bone pain or swelling as possible signs of osteosarcoma, skin checks and sun protection; carriers have no expected health effects.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ANAPC1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where ANAPC1 sits. ANAPC1 and 5 genes near it on chromosome 2, from 111,325,917 to 112,325,916.Chromosome 22q13p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3111.4 Mb111.6 Mb111.8 Mb112 Mb112.2 MbANAPC1: 111,767,640–111,884,193, reverse strandANAPC1MERTK: 111,898,456–112,040,637, forward strandMERTKTMEM87B: 112,055,202–112,119,870, forward strandTMEM87BFBLN7: 112,138,363–112,188,218, forward strandFBLN7ZC3H8: 112,211,529–112,255,151, reverse strandZC3H8ZC3H6: 112,275,565–112,340,059, forward strandZC3H6Diagram of ANAPC1: 48 exons on the reverse strand of chromosome 2Exon 12: 1 known disease-causing siteExon 48: 111,767,640–111,769,406, 1,767 basesExon 47: 111,772,341–111,772,475, 135 basesExon 46: 111,776,859–111,777,057, 199 basesExon 45: 111,778,675–111,778,770, 96 basesExon 44: 111,780,299–111,780,385, 87 basesExon 43: 111,782,369–111,782,507, 139 basesExon 42: 111,783,897–111,783,964, 68 basesExon 41: 111,784,323–111,784,400, 78 basesExon 40: 111,785,360–111,785,477, 118 basesExon 39: 111,788,234–111,788,320, 87 basesExon 38: 111,792,362–111,792,555, 194 basesExon 37: 111,794,078–111,794,131, 54 basesExon 36: 111,794,233–111,794,323, 91 basesExon 35: 111,794,818–111,794,894, 77 basesExon 34: 111,800,797–111,800,871, 75 basesExon 33: 111,802,428–111,802,506, 79 basesExon 32: 111,803,448–111,803,530, 83 basesExon 31: 111,803,705–111,803,839, 135 basesExon 30: 111,805,802–111,805,893, 92 basesExon 29: 111,808,947–111,809,181, 235 basesExon 28: 111,815,370–111,815,641, 272 basesExon 27: 111,818,840–111,818,958, 119 basesExon 26: 111,821,239–111,821,453, 215 basesExon 25: 111,822,422–111,822,600, 179 basesExon 24: 111,824,966–111,825,036, 71 basesExon 23: 111,825,131–111,825,167, 37 basesExon 22: 111,825,777–111,825,855, 79 basesExon 21: 111,831,286–111,831,434, 149 basesExon 20: 111,833,220–111,833,311, 92 basesExon 19: 111,834,604–111,834,872, 269 basesExon 18: 111,838,438–111,838,512, 75 basesExon 17: 111,843,412–111,843,599, 188 basesExon 16: 111,847,138–111,847,198, 61 basesExon 15: 111,847,725–111,847,865, 141 basesExon 14: 111,850,776–111,850,910, 135 basesExon 13: 111,856,614–111,856,679, 66 basesExon 12: 111,856,796–111,856,886, 91 basesExon 11: 111,858,306–111,858,401, 96 basesExon 10: 111,862,389–111,862,598, 210 basesExon 9: 111,863,675–111,863,895, 221 basesExon 8: 111,864,806–111,864,951, 146 basesExon 7: 111,868,023–111,868,096, 74 basesExon 6: 111,872,630–111,872,712, 83 basesExon 5: 111,873,308–111,873,408, 101 basesExon 4: 111,873,613–111,873,664, 52 basesExon 3: 111,878,810–111,878,971, 162 basesExon 2: 111,880,613–111,880,849, 237 basesExon 1: 111,883,942–111,884,193, 252 bases484540353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.8 kb of the gene's 116.6 kb; 5,835 of those bases code for the protein.

How a genome test reads ANAPC1

2

positions in ANAPC1 where ClinVar classes a change as pathogenic or likely pathogenic

2 of them (100%) fall in regions short reads find hard.

  • Low mappability (2 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (2 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 116.6 kb of ANAPC1, introns included, not only the 7.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ANAPC1 gene: anaphase promoting complex subunit 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/anapc1

Vancouver

Dante Labs. ANAPC1 gene: anaphase promoting complex subunit 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/anapc1

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