Skip to content
Use your HSA or FSA funds

Gene

PI4KA

phosphatidylinositol 4-kinase alpha

Summary

Cytogenetic location
22q11.21
Coordinates
Chromosome 22: 20,707,691–20,858,811 (GRCh38)
Exons
55 exons across 151.1 kb
Protein
2,102 amino acids
Also known as
PI4K-ALPHA, pi4K230
Previous symbols
PIK4CA
MANE Select transcript
ENST00000255882.11NM_058004.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PI4KA yet. The test sequences your whole genome, so your data includes it all the same.

How PI4KA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where PI4KA sits. PI4KA and 17 genes near it on chromosome 22, from 20,283,251 to 21,283,250.Chromosome 2222q11.21p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3320.4 Mb20.6 Mb20.8 Mb21 Mb21.2 MbDGCR6L: 20,312,140–20,320,085, reverse strandDGCR6LZNF74: 20,394,115–20,409,406, forward strandZNF74SCARF2: 20,424,584–20,438,332, reverse strandSCARF2: 20,429,241–20,446,620, reverse strandKLHL22: 20,441,519–20,496,893, reverse strandKLHL22MED15: 20,495,913–20,587,632, forward strandMED15PI4KA: 20,707,691–20,858,811, reverse strandPI4KASERPIND1: 20,774,092–20,787,721, forward strandSERPIND1SNAP29: 20,858,537–20,891,218, forward strandSNAP29CRKL: 20,917,353–20,953,747, forward strandCRKLAIFM3: 20,965,108–20,981,364, forward strandAIFM3LZTR1: 20,981,979–20,999,037, forward strandLZTR1THAP7: 20,999,104–21,002,196, reverse strandTHAP7LRRC74BNL: 21,007,199–21,014,301, reverse strandLRRC74BNL: 21,008,247–21,032,572, reverse strandP2RX6: 21,009,808–21,028,013, forward strandSLC7A4: 21,028,715–21,032,933, reverse strandLRRC74B: 21,045,941–21,064,168, forward strandDiagram of PI4KA: 55 exons on the reverse strand of chromosome 22Exon 53: 1 known disease-causing siteExon 52: 1 known disease-causing siteExon 51: 1 known disease-causing siteExon 48: 1 known disease-causing siteExon 46: 1 known disease-causing siteExon 44: 1 known disease-causing siteExon 41: 2 known disease-causing sitesExon 39: 1 known disease-causing siteExon 36: 1 known disease-causing siteExon 35: 1 known disease-causing siteExon 34: 2 known disease-causing sitesExon 32: 1 known disease-causing siteExon 30: 1 known disease-causing siteExon 29: 3 known disease-causing sitesExon 25: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 16: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 6: 4 known disease-causing sitesExon 3: 1 known disease-causing siteExon 55: 20,707,691–20,708,098, 408 basesExon 54: 20,709,296–20,709,379, 84 basesExon 53: 20,709,908–20,709,997, 90 basesExon 52: 20,710,699–20,710,858, 160 basesExon 51: 20,711,341–20,711,461, 121 basesExon 50: 20,712,486–20,712,611, 126 basesExon 49: 20,712,693–20,712,797, 105 basesExon 48: 20,713,281–20,713,390, 110 basesExon 47: 20,714,458–20,714,528, 71 basesExon 46: 20,714,628–20,714,700, 73 basesExon 45: 20,717,708–20,717,778, 71 basesExon 44: 20,718,693–20,718,822, 130 basesExon 43: 20,721,298–20,721,418, 121 basesExon 42: 20,726,488–20,726,541, 54 basesExon 41: 20,727,230–20,727,397, 168 basesExon 40: 20,727,774–20,727,864, 91 basesExon 39: 20,729,313–20,729,506, 194 basesExon 38: 20,729,632–20,729,711, 80 basesExon 37: 20,729,892–20,730,011, 120 basesExon 36: 20,732,971–20,733,098, 128 basesExon 35: 20,733,736–20,733,843, 108 basesExon 34: 20,734,043–20,734,194, 152 basesExon 33: 20,734,395–20,734,553, 159 basesExon 32: 20,742,228–20,742,355, 128 basesExon 31: 20,742,608–20,742,764, 157 basesExon 30: 20,744,628–20,744,720, 93 basesExon 29: 20,747,583–20,747,702, 120 basesExon 28: 20,749,905–20,749,994, 90 basesExon 27: 20,751,293–20,751,376, 84 basesExon 26: 20,751,674–20,751,755, 82 basesExon 25: 20,752,903–20,753,027, 125 basesExon 24: 20,753,110–20,753,180, 71 basesExon 23: 20,761,304–20,761,386, 83 basesExon 22: 20,764,817–20,764,950, 134 basesExon 21: 20,765,100–20,765,236, 137 basesExon 20: 20,765,585–20,765,693, 109 basesExon 19: 20,793,193–20,793,243, 51 basesExon 18: 20,796,146–20,796,314, 169 basesExon 17: 20,798,584–20,798,687, 104 basesExon 16: 20,799,093–20,799,276, 184 basesExon 15: 20,799,671–20,799,766, 96 basesExon 14: 20,801,973–20,802,105, 133 basesExon 13: 20,803,191–20,803,320, 130 basesExon 12: 20,804,300–20,804,400, 101 basesExon 11: 20,804,974–20,805,165, 192 basesExon 10: 20,807,362–20,807,458, 97 basesExon 9: 20,810,967–20,811,032, 66 basesExon 8: 20,813,358–20,813,506, 149 basesExon 7: 20,818,483–20,818,549, 67 basesExon 6: 20,819,641–20,819,900, 260 basesExon 5: 20,820,539–20,820,611, 73 basesExon 4: 20,824,326–20,824,414, 89 basesExon 3: 20,834,562–20,834,655, 94 basesExon 2: 20,838,615–20,838,731, 117 basesExon 1: 20,858,570–20,858,811, 242 bases55504540353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.8 kb of the gene's 151.1 kb; 6,309 of those bases code for the protein.

How a genome test reads PI4KA

39

positions in PI4KA where ClinVar classes a change as pathogenic or likely pathogenic

12 of them (31%) fall in regions short reads find hard.

  • Low mappability (10 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (12 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 151.1 kb of PI4KA, introns included, not only the 6.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PI4KA gene: phosphatidylinositol 4-kinase alpha. Retrieved 17 October 2026, from https://dantelabs.com/genes/pi4ka

Vancouver

Dante Labs. PI4KA gene: phosphatidylinositol 4-kinase alpha [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pi4ka

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test