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Gene

NOP10

NOP10 ribonucleoprotein

Summary

Cytogenetic location
15q14
Coordinates
Chromosome 15: 34,341,719–34,343,136 (GRCh38)
Exons
2 exons across 1.4 kb
Protein
64 amino acids
Also known as
NOP10P, MGC70651
Previous symbols
NOLA3
MANE Select transcript
ENST00000328848.6NM_018648.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dyskeratosis Congenita

    • Dyskeratosis congenita (DC) is a rare ectodermal dysplasia that often presents with the classic triad of nail dysplasia, skin pigmentary changes, and oral leukoplakia associated with a high risk of bone marrow failure (BMF) and cancer.

      • 1 GenCC submitter rates it definitive or strong

How NOP10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 15, with a bracket where NOP10 sits. NOP10 and 14 genes near it on chromosome 15, from 33,842,428 to 34,842,427.Chromosome 1515q14p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.334 Mb34.2 Mb34.4 Mb34.6 Mb34.8 MbRYR3: 33,310,947–33,866,121, forward strandRYR3AVEN: 33,836,372–34,075,155, reverse strandAVENCHRM5: 33,968,260–34,067,458, forward strandCHRM5EMC7: 34,075,970–34,101,929, reverse strandEMC7PGBD4: 34,102,083–34,108,686, forward strandPGBD4KATNBL1: 34,140,365–34,210,119, reverse strandKATNBL1EMC4: 34,224,997–34,230,161, forward strandEMC4SLC12A6: 34,229,784–34,338,060, reverse strandSLC12A6NOP10: 34,341,719–34,343,136, reverse strandNOP10NUTM1: 34,343,315–34,357,737, forward strandNUTM1LPCAT4: 34,358,633–34,367,706, reverse strandLPCAT4GOLGA8A: 34,378,935–34,437,851, reverse strandGOLGA8AGOLGA8B: 34,525,084–34,588,503, reverse strandGOLGA8BGJD2: 34,751,032–34,755,003, reverse strandGJD2ACTC1: 34,790,107–34,795,912, reverse strandACTC1Diagram of NOP10: 2 exons on the reverse strand of chromosome 15Exon 1: 1 known disease-causing siteExon 2: 34,341,719–34,342,108, 390 basesExon 1: 34,343,020–34,343,136, 117 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.5 kb of the gene's 1.4 kb; 195 of those bases code for the protein.

How a genome test reads NOP10

1

position in NOP10 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1.4 kb of NOP10, introns included, not only the 0.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NOP10 gene: NOP10 ribonucleoprotein. Retrieved 16 October 2026, from https://dantelabs.com/genes/nop10

Vancouver

Dante Labs. NOP10 gene: NOP10 ribonucleoprotein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/nop10

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